| Literature DB >> 19226124 |
Thomas Tricotet1, Patricia Fleming, Juliet Cotter, Anne-Marie L Hogan, Carsten Strohmann, Viktoria H Gessner, Donal F O'Shea.
Abstract
A stereochemistry-controlled suppression of carbolithiation facilitated a regioselective vinyl C-H lithiation of cis-stilbenes allowing routine regio- and stereoselective access to polysubstituted alkenes and heterocycles. This unique selectivity was obtained for numerous directing groups and could be rationalized with DFT computational studies and an experimental mechanistic illustration of a unique anion migration.Entities:
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Year: 2009 PMID： 19226124 DOI： 10.1021/ja809941n
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419