Literature DB >> 19225736

"Iatrogenicity cascade": doing harm by treating harm?

Claudia Christina Wagner1, Jerome Biollaz, Markus Zeitlinger, Thierry Buclin.   

Abstract

An electronic survey on substance-induced epileptic crisis was conducted in order to investigate whether doctors, who recognise their own prescription errors, increase their therapeutic aggressiveness, resulting in a so-called "iatrogenicity cascade". Two pairs of clinical vignettes were constructed, in which a patient suffers from iatrogenic (original version) or non-iatrogenic (control version) epileptic crisis. Vignettes were randomised and sent to doctors at the University Hospital of Lausanne, Switzerland, at an interval of 3 weeks. The results of the present survey in the surveyed population of doctors suggest that inappropriate prescription does not increase therapeutic aggressiveness.

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Mesh:

Year:  2009        PMID: 19225736     DOI: 10.1007/s10354-008-0579-y

Source DB:  PubMed          Journal:  Wien Med Wochenschr        ISSN: 0043-5341


  12 in total

1.  Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412.

Authors:  Ganesh Suntharalingam; Meghan R Perry; Stephen Ward; Stephen J Brett; Andrew Castello-Cortes; Michael D Brunner; Nicki Panoskaltsis
Journal:  N Engl J Med       Date:  2006-08-14       Impact factor: 91.245

2.  Would physicians override a do-not-resuscitate order when a cardiac arrest is iatrogenic?

Authors:  D J Casarett; C B Stocking; M Siegler
Journal:  J Gen Intern Med       Date:  1999-01       Impact factor: 5.128

3.  Overriding a patient's refusal of treatment after an iatrogenic complication.

Authors:  D Casarett; L F Ross
Journal:  N Engl J Med       Date:  1997-06-26       Impact factor: 91.245

4.  Impact of adverse events on prescribing warfarin in patients with atrial fibrillation: matched pair analysis.

Authors:  Niteesh K Choudhry; Geoffrey M Anderson; Andreas Laupacis; Dennis Ross-Degnan; Sharon-Lise T Normand; Stephen B Soumerai
Journal:  BMJ       Date:  2006-01-10

5.  Biases in how physicians choose to withdraw life support.

Authors:  N A Christakis; D A Asch
Journal:  Lancet       Date:  1993-09-11       Impact factor: 79.321

6.  Fatal seizures after flumazenil administration in a patient with mixed overdose.

Authors:  G P Haverkos; R P DiSalvo; T E Imhoff
Journal:  Ann Pharmacother       Date:  1994-12       Impact factor: 3.154

7.  Pharmacological overtreatment in epilepsy: mechanisms and management.

Authors:  Dieter Schmidt; Christian Elger; Gregory L Holmes
Journal:  Epilepsy Res       Date:  2002-11       Impact factor: 3.045

Review 8.  Drug therapy.

Authors:  P A Rochon; J H Gurwitz
Journal:  Lancet       Date:  1995-07-01       Impact factor: 79.321

9.  Initiation of antihypertensive treatment during nonsteroidal anti-inflammatory drug therapy.

Authors:  J H Gurwitz; J Avorn; R L Bohn; R J Glynn; M Monane; H Mogun
Journal:  JAMA       Date:  1994-09-14       Impact factor: 56.272

10.  Cefepime-induced non-convulsive status epilepticus in a peritoneal dialysis patient.

Authors:  Harika Alpay; Ozge Altun; Nese Karaaslan Biyikli
Journal:  Pediatr Nephrol       Date:  2004-02-21       Impact factor: 3.714

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