Bharat Thyagarajan1, Lewis J Smith2, R Graham Barr3, Myron D Gross1, Akshay Sood4, Ravi Kalhan2, David R Jacobs5. 1. Department of Laboratory Medicine and Pathology, Medical School, Minneapolis, MN. 2. Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL. 3. Department of Medicine, Columbia University, New York, NY. 4. Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, NM. 5. Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; Department of Nutrition, University of Oslo, Oslo, Norway. Electronic address: jacobs@epi.umn.edu.
Abstract
BACKGROUND: Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study. METHODS: Spirometry testing was conducted at years 5, 10, and 20. ICAM-1 and P-selectin were assayed at year 15. RESULTS: Complete data were obtained from 2,455 participants. We first predicted year-20 lung function from year-15 ICAM-1 concentration data. After controlling for race, gender, height, age, physical activity, smoking status, alcohol intake, BMI, and asthma status, all taken at year 15, the year-20 FVC was 164 mL higher (p < 0.0001) and FEV(1) was 164 mL higher (p = 0.0003) in the lowest ICAM-1 concentration quartile than the highest ICAM-1 quartile, whereas the FEV(1)/FVC ratio showed no association (p = 0.25). We then predicted the year-15 ICAM-1 concentration from year-5 lung function and change in lung function (year 10 - year 5). The year-15 ICAM-1 concentration was about 13 ng/mL higher in the lowest vs highest quartile of either the year-5 FVC (p = 0.01) or year-5 FEV(1) (p = 0.005). Year-15 ICAM-1 concentration was unrelated to year-5 FEV(1)/FVC ratio. Greater loss in FVC and FEV(1) (year 10 - year 5) also was associated with higher year-15 ICAM-1 concentrations. Associations between P-selectin and lung function followed a similar but weaker pattern to that observed for ICAM-1. CONCLUSIONS: These data suggest a bidirectional association between circulating adhesion molecules, such as ICAM-1 and P-selectin, and pattern of lung function change in adults.
BACKGROUND: Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study. METHODS: Spirometry testing was conducted at years 5, 10, and 20. ICAM-1 and P-selectin were assayed at year 15. RESULTS: Complete data were obtained from 2,455 participants. We first predicted year-20 lung function from year-15 ICAM-1 concentration data. After controlling for race, gender, height, age, physical activity, smoking status, alcohol intake, BMI, and asthma status, all taken at year 15, the year-20 FVC was 164 mL higher (p < 0.0001) and FEV(1) was 164 mL higher (p = 0.0003) in the lowest ICAM-1 concentration quartile than the highest ICAM-1 quartile, whereas the FEV(1)/FVC ratio showed no association (p = 0.25). We then predicted the year-15 ICAM-1 concentration from year-5 lung function and change in lung function (year 10 - year 5). The year-15 ICAM-1 concentration was about 13 ng/mL higher in the lowest vs highest quartile of either the year-5 FVC (p = 0.01) or year-5 FEV(1) (p = 0.005). Year-15 ICAM-1 concentration was unrelated to year-5 FEV(1)/FVC ratio. Greater loss in FVC and FEV(1) (year 10 - year 5) also was associated with higher year-15 ICAM-1 concentrations. Associations between P-selectin and lung function followed a similar but weaker pattern to that observed for ICAM-1. CONCLUSIONS: These data suggest a bidirectional association between circulating adhesion molecules, such as ICAM-1 and P-selectin, and pattern of lung function change in adults.
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Authors: J Michael Wells; Laura A Colangelo; Lakshmi Sivarajan; Bharat Thyagarajan; Mark T Dransfield; Carlos Iribarren; Paul A Reyfman; David R Jacobs; George R Washko; Ravi Kalhan Journal: Eur Respir J Date: 2019-01-17 Impact factor: 16.671
Authors: Bharat Thyagarajan; Katie A Meyer; Lewis J Smith; William S Beckett; O Dale Williams; Myron D Gross; David R Jacobs Journal: Am J Clin Nutr Date: 2011-09-14 Impact factor: 7.045
Authors: Carrie P Aaron; Joseph E Schwartz; Suzette J Bielinski; Eric A Hoffman; John H M Austin; Elizabeth C Oelsner; Kathleen M Donohue; Ravi Kalhan; Cecilia Berardi; Joel D Kaufman; David R Jacobs; Russell P Tracy; R Graham Barr Journal: Respir Med Date: 2014-10-22 Impact factor: 3.415
Authors: E C Oelsner; T D Pottinger; K M Burkart; M Allison; S G Buxbaum; N N Hansel; R Kumar; E K Larkin; L A Lange; L R Loehr; S J London; G T O'Connor; G Papanicolaou; M F Petrini; D Rabinowitz; S Raghavan; S Redline; B Thyagarajan; R P Tracy; J B Wilk; W B White; S S Rich; R G Barr Journal: Biomarkers Date: 2013-04-05 Impact factor: 2.658
Authors: Maan Moualla; Clifford Qualls; Alexander Arynchyn; Bharat Thyagarajan; Ravi Kalhan; Lewis J Smith; John J Carr; David R Jacobs; Akshay Sood Journal: Thorax Date: 2017-07-20 Impact factor: 9.102