OBJECTIVE: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population. METHODS: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking. RESULTS: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups. CONCLUSION: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.
OBJECTIVE: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population. METHODS: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking. RESULTS: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups. CONCLUSION: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.
Authors: Mariana Fernández-Caggiano; Javier Barallobre-Barreiro; Ignacio Rego-Pérez; María G Crespo-Leiro; María Jesus Paniagua; Zulaika Grillé; Francisco J Blanco; Nieves Doménech Journal: PLoS One Date: 2012-08-28 Impact factor: 3.240
Authors: Gavin Hudson; Kalliope Panoutsopoulou; Ian Wilson; Lorraine Southam; Nigel W Rayner; Nigel Arden; Fraser Birrell; Ian Carluke; Andrew Carr; Kay Chapman; Panos Deloukas; Michael Doherty; Andrew McCaskie; William E R Ollier; Stuart H Ralston; Mike R Reed; Tim D Spector; Ana M Valdes; Gillian A Wallis; J Mark Wilkinson; Eleftheria Zeggini; David C Samuels; John Loughlin; Patrick F Chinnery Journal: Ann Rheum Dis Date: 2012-09-14 Impact factor: 19.103