Literature DB >> 19224296

Long-term functional and quality of life outcomes of patients after repair of large perianal skin defects for Paget's and Bowen's disease.

Alissa Conklin1, Imran Hassan, Heidi K Chua, E Dawn Wietfeldt, Dirk R Larson, Kristine A Thomsen, Sanhat Nivatvongs.   

Abstract

INTRODUCTION: The assessment of long- term functional and quality of life outcomes of these patients following repair of large defects after surgical excision has not been reported.
METHODS: Between 1992 and 2004, at two institutions, 18 patients underwent repair of a perianal defect for Paget's disease (n = 8) or Bowen's disease (n = 10) and were alive with intestinal continuity at last follow-up. Patients were mailed the fecal incontinence quality of life scale (FIQL) and the SF-36.
RESULTS: Fourteen patients (78%) responded. Median follow-up for responders was 5 years. Mean age was 65 years with 12 females. Subcutaneous skin flaps (11) and split-thickness skin grafts (three) were used to repair the perianal defects, which were circumferential in 11 patients (79%). Nine patients reported incontinence and completed the FIQL. The FIQL scores of patients reporting incontinence were lower for lifestyle, coping/behavior, and embarrassment but not significantly different for depression compared to patients without incontinence. SF-36 scores of the patients were not significantly different from the normative population.
CONCLUSION: Functional results after repair of large perianal defects are acceptable and overall quality of life (QOL) is similar to the normative population although a large proportion of patients have some form of incontinence that impacts certain aspects of their QOL.

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Year:  2009        PMID: 19224296     DOI: 10.1007/s11605-009-0822-x

Source DB:  PubMed          Journal:  J Gastrointest Surg        ISSN: 1091-255X            Impact factor:   3.452


  40 in total

1.  Fecal Incontinence Quality of Life Scale: quality of life instrument for patients with fecal incontinence.

Authors:  T H Rockwood; J M Church; J W Fleshman; R L Kane; C Mavrantonis; A G Thorson; S D Wexner; D Bliss; A C Lowry
Journal:  Dis Colon Rectum       Date:  2000-01       Impact factor: 4.585

2.  Treatment options for perianal Bowen's disease: survery of American Society of Colon and Rectal Surgeons Members.

Authors:  R K Cleary; J D Schaldenbrand; J J Fowler; J M Schuler; R M Lampman
Journal:  Am Surg       Date:  2000-07       Impact factor: 0.688

Review 3.  Imiquimod: a review.

Authors:  Aditya K Gupta; Melanie Browne; Robyn Bluhm
Journal:  J Cutan Med Surg       Date:  2002-10-09       Impact factor: 2.092

Review 4.  Treatment of primary limited cutaneous extramammary Paget's disease with topical imiquimod monotherapy: two case reports.

Authors:  Jennifer C Zampogna; Franklin P Flowers; William I Roth; Ashraf M Hassenein
Journal:  J Am Acad Dermatol       Date:  2002-10       Impact factor: 11.527

Review 5.  Epidemiology of fecal incontinence.

Authors:  Richard L Nelson
Journal:  Gastroenterology       Date:  2004-01       Impact factor: 22.682

6.  Treatment of limited extent extramammary Paget's disease with 5 percent imiquimod cream.

Authors:  Christy Badgwell; Ted Rosen
Journal:  Dermatol Online J       Date:  2006-01-27

7.  V-Y advancement posterior thigh fasciocutaneous flaps for total anal canal and large perianal defects.

Authors:  H Terashi; O Shibata; A Yamamoto; Y Kudo; T Tadokoro; S Kurata; S Takayasu
Journal:  Ann Plast Surg       Date:  1996-09       Impact factor: 1.539

8.  Long-term outcome of perianal Paget's disease.

Authors:  Martin D McCarter; Stuart H Q Quan; Klaus Busam; Philip P Paty; Douglas Wong; Jose G Guillem
Journal:  Dis Colon Rectum       Date:  2003-05       Impact factor: 4.585

9.  Topical 5-fluorouracil in the management of extensive anal Bowen's disease: a preferred approach.

Authors:  Bruce D Graham; Allen B Jetmore; Jerry E Foote; L Kirk Arnold
Journal:  Dis Colon Rectum       Date:  2005-03       Impact factor: 4.585

10.  Topical treatment of Bowen's disease with 5-Fluorouracil.

Authors:  Howard Bargman; Jacqueline Hochman
Journal:  J Cutan Med Surg       Date:  2002-11-27       Impact factor: 2.092

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  5 in total

1.  Neoplasms of anal canal and perianal skin.

Authors:  Daniel Leonard; David Beddy; Eric J Dozois
Journal:  Clin Colon Rectal Surg       Date:  2011-03

2.  Malignancies of the anal margin and perianal skin.

Authors:  E Dawn Wietfeldt; James Thiele
Journal:  Clin Colon Rectal Surg       Date:  2009-05

3.  Extramammary Perianal Paget's Disease.

Authors:  M N Al Hallak; N Zouain
Journal:  Case Rep Gastroenterol       Date:  2009-11-20

4.  Negative pressure wound therapy combined with skin grafting improves surgical wound healing in the perianal area.

Authors:  Shi Jia-Zi; Zhai Xiao; Li Jun-Hui; Xue Chun-Yu; Bi Hong-da
Journal:  Medicine (Baltimore)       Date:  2016-08       Impact factor: 1.889

5.  Management of Adenocarcinoma in the Setting of Recently Operated Perianal Paget's Disease.

Authors:  Margaret E Clark; Andrew T Schlussel; Ronald A Gagliano
Journal:  Case Rep Surg       Date:  2013-05-19
  5 in total

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