| Literature DB >> 19223187 |
Xiaokui Wang1, Jian Lin, Yao Chen, Wu Zhong, Guoming Zhao, Hongying Liu, Site Li, Lili Wang, Song Li.
Abstract
Several novel series of C75 derivatives were synthesized and evaluated for their FAS inhibitory activities. The results showed compound 4-methylene-2-octyl-5-oxo-tetrahydro-thiophene-3-carboxylic acid (1c) had more effective FAS inhibitory (IC(50) was 2.56 microM and T.I. was 9.26) and potent anti-tumor activities on HL60 and Hela cells in vitro (IC(50) were 5.38 microM and 46.10 microM, respectively).Entities:
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Year: 2009 PMID： 19223187 DOI： 10.1016/j.bmc.2009.01.050
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641