| Literature DB >> 19223118 |
Yanke Chen1, Hongxin Zhang, Xingchun Gou, Yohei Horikawa, Jinliang Xing, Zhinan Chen.
Abstract
Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.Entities:
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Year: 2009 PMID： 19223118 DOI： 10.1016/j.canlet.2009.01.004
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679