Literature DB >> 19223020

Helminths and our immune system: friend or foe?

Helena Helmby1.   

Abstract

Helminths are able to modulate and suppress the hosts' immune response in order to promote their own survival. This ability to alter immune responses could be of potential detriment to the host if it interferes with the development of protective immune responses against other infections. However, helminth infections have also been suggested to be beneficial in the control of excessive inflammatory reactions. In this review I will highlight some of the data suggesting both positive and negative effects of helminth infections in humans and in experimental models.

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Year:  2009        PMID： 19223020     DOI： 10.1016/j.parint.2009.02.001

Source DB:  PubMed          Journal:  Parasitol Int        ISSN： 1383-5769            Impact factor:   2.230


  8 in total

Review 1.  Helminth-derived immunomodulators: can understanding the worm produce the pill?

Authors:  William Harnett; Margaret M Harnett
Journal:  Nat Rev Immunol       Date:  2010-03-12       Impact factor: 53.106

2.  Impact of treatment of gastrointestinal nemathelminths on body weight of sheep and goats.

Authors:  Deepesh Sharma; Stuti Vatsya; Rajeev Ranjan Kumar
Journal:  J Parasit Dis       Date:  2014-09-25

Review 3.  Human helminth therapy to treat inflammatory disorders - where do we stand?

Authors:  Helena Helmby
Journal:  BMC Immunol       Date:  2015-03-26       Impact factor: 3.615

4.  The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections.

Authors:  Neima Briggs; Jill Weatherhead; K Jagannadha Sastry; Peter J Hotez
Journal:  PLoS Negl Trop Dis       Date:  2016-09-15

5.  Nematode-derived proteins suppress proliferation and cytokine production of antigen-specific T cells via induction of cell death.

Authors:  Wiebke Hartmann; Yannick Brenz; Manchang Tanyi Kingsley; Irene Ajonina-Ekoti; Norbert W Brattig; Eva Liebau; Minka Breloer
Journal:  PLoS One       Date:  2013-06-21       Impact factor: 3.240

Review 6.  Risk factors for adverse prognosis and death in American visceral leishmaniasis: a meta-analysis.

Authors:  Vinícius Silva Belo; Claudio José Struchiner; David Soeiro Barbosa; Bruno Warlley Leandro Nascimento; Marco Aurélio Pereira Horta; Eduardo Sérgio da Silva; Guilherme Loureiro Werneck
Journal:  PLoS Negl Trop Dis       Date:  2014-07-24

7.  Schistosoma japonicum HSP60-derived peptide SJMHE1 suppresses delayed-type hypersensitivity in a murine model.

Authors:  Xuefeng Wang; Jun Wang; Yong Liang; Hongchang Ni; Liang Shi; Chengcheng Xu; Yuepeng Zhou; Yuting Su; Xiao Mou; Deyu Chen; Chaoming Mao
Journal:  Parasit Vectors       Date:  2016-03-12       Impact factor: 3.876

8.  Helminths as an alternative therapy for intestinal diseases.

Authors:  Aytan Miranda Sipahi; Daniel Machado Baptista
Journal:  World J Gastroenterol       Date:  2017-09-07       Impact factor: 5.742
  8 in total

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