PURPOSE: We examined potential differences in the effects of pathology type on language lateralization in pediatric epilepsy. METHODS: We examined findings from intracarotid sodium amobarbital procedure (IAP/Wada) in a large consecutive sample of children with refractory epilepsy. Subjects were assigned to one of three pathology groups: developmental (n = 28), acquired (n = 26), and tumor (n = 20); groups were compared for language lateralization. RESULTS: Rates of atypical language lateralization did not differ across groups. Greater than half of the subjects with left hemisphere insults and seizure onset before 6 years of age had atypical language lateralization, independent of pathology type. DISCUSSION: Atypical language lateralization may occur in the context of developmental, acquired, and/or tumor pathology.
PURPOSE: We examined potential differences in the effects of pathology type on language lateralization in pediatric epilepsy. METHODS: We examined findings from intracarotid sodium amobarbital procedure (IAP/Wada) in a large consecutive sample of children with refractory epilepsy. Subjects were assigned to one of three pathology groups: developmental (n = 28), acquired (n = 26), and tumor (n = 20); groups were compared for language lateralization. RESULTS: Rates of atypical language lateralization did not differ across groups. Greater than half of the subjects with left hemisphere insults and seizure onset before 6 years of age had atypical language lateralization, independent of pathology type. DISCUSSION: Atypical language lateralization may occur in the context of developmental, acquired, and/or tumor pathology.
Authors: Rochelle Caplan; Jennifer Levitt; Prabha Siddarth; Keng Nei Wu; Suresh Gurbani; W Donald Shields; Raman Sankar Journal: Epilepsy Behav Date: 2010-02-10 Impact factor: 2.937
Authors: Maureen Dennis; Brenda J Spiegler; Jenifer J Juranek; Erin D Bigler; O Carter Snead; Jack M Fletcher Journal: Neurosci Biobehav Rev Date: 2013-10-03 Impact factor: 8.989