| Literature DB >> 19222168 |
Eric Ferrer1, Ramon Alibés, Félix Busqué, Marta Figueredo, Josep Font, Pedro de March.
Abstract
An enantiodivergent synthesis of several cyclohexenyl nucleosides has been efficiently completed starting from the enantiopure hydrobenzoin-derived monoketal of cyclohex-2-en-1,4-dione, (+)-5. Stereodiversity was accomplished on the base coupling step. This methodology has proved to be useful for the synthesis of enantiopure pyrimidine and purine nucleoside analogues, which anti-HIV activity has been evaluated.Entities:
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Year: 2009 PMID： 19222168 DOI： 10.1021/jo802492g
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354