Literature DB >> 19222062

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.

Tommaso Cupido1, Paul G Rack, Ari J Firestone, Joel M Hyman, Kyuho Han, Surajit Sinha, Cory A Ocasio, James K Chen.   

Abstract

Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation (see figure).

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Year:  2009        PMID： 19222062     DOI： 10.1002/anie.200805666

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

1.  Arhgap36-dependent activation of Gli transcription factors.

Authors:  Paul G Rack; Jun Ni; Alexander Y Payumo; Vien Nguyen; J Aaron Crapster; Volker Hovestadt; Marcel Kool; David T W Jones; John K Mich; Ari J Firestone; Stefan M Pfister; Yoon-Jae Cho; James K Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-14       Impact factor: 11.205

2.  Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector.

Authors:  Jynho Kim; John J Lee; James Kim; Dale Gardner; Philip A Beachy
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 3.  Novel investigational drugs for basal cell carcinoma.

Authors:  Po-Lin So; Jean Y Tang; Ervin H Epstein
Journal:  Expert Opin Investig Drugs       Date:  2010-09       Impact factor: 6.206

4.  Chemical and biological studies of nakiterpiosin and nakiterpiosinone.

Authors:  Shuanhu Gao; Qiaoling Wang; Lily Jun-Shen Huang; Lawrence Lum; Chuo Chen
Journal:  J Am Chem Soc       Date:  2010-01-13       Impact factor: 15.419

5.  Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.

Authors:  Moe R Mahjoub; Tim Stearns
Journal:  Curr Biol       Date:  2012-07-26       Impact factor: 10.834

6.  Selective, C-3 Friedel-Crafts acylation to generate functionally diverse, acetylated Imidazo[1,2-a]pyridine derivatives.

Authors:  Brendan Frett; Nicholas McConnell; Anupreet Kharbanda; Gunaganti Naresh; Benjamin Rounseville; Christina Warner; John Chang; Natalie Debolske; Hong-Yu Li
Journal:  Tetrahedron       Date:  2018-07-17       Impact factor: 2.457

7.  Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells.

Authors:  Helen O Oladapo; Michael Tarpley; Scott J Sauer; Kezia A Addo; Shalonda M Ingram; Dillon Strepay; Ben K Ehe; Lhoucine Chdid; Michael Trinkler; Jose R Roques; David B Darr; Jodie M Fleming; Gayathri R Devi; Kevin P Williams
Journal:  Cancer Lett       Date:  2017-09-28       Impact factor: 8.679

8.  Tubulin is a molecular target of the Wnt-activating chemical probe.

Authors:  Yasunori Fukuda; Osamu Sano; Kenichi Kazetani; Koji Yamamoto; Hidehisa Iwata; Junji Matsui
Journal:  BMC Biochem       Date:  2016-05-20       Impact factor: 4.059

9.  Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Authors:  Bomi Jung; Ana C Messias; Kenji Schorpp; Arie Geerlof; Günter Schneider; Dieter Saur; Kamyar Hadian; Michael Sattler; Erich E Wanker; Stefan Hasenöder; Heiko Lickert
Journal:  Sci Rep       Date:  2016-03-02       Impact factor: 4.379
  9 in total

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