OBJECTIVE: To study the hypothesis that concentrations of procollagen propeptides of type I and III collagens (PICP and PIIINP, respectively) and the carboxyterminal telopeptide of type I collagen (ICTP) in subdural haematoma increase in a time-dependent manner as a sign of dural collagen synthesis after head injury. METHODS: Thirty-six patients with subdural haematoma were operated. Subdural haematoma fluid samples were assayed for the concentrations of PICP, PIIINP and ICTP by specific radioimmunoassays. RESULTS: High concentrations of PICP, PIIINP and ICTP were found in subdural haematoma. The mean concentration of PICP in the 36 subdural haematoma samples was 11.8 (SD 9.27) mg/l, the concentration of PIIINP 590 (SD 302) microg/l and that of ICTP 32.0 (SD 12.1) microg/l. The time elapsed from the alleged head injury to operation could be defined in 30 patients. The concentrations of PICP, PIIINP and ICTP in subdural haematoma increased rapidly during the first two weeks after head injury and then stayed high for at least three months. CONCLUSIONS: High concentrations of procollagen propeptides were found in subdural haematoma samples of different haematoma age. Concentrations of these propeptides seem to follow a time-dependent course. The elevation of the concentrations of procollagen propeptides in subdural haematoma may be regarded as a sign of sustained dural collagen synthesis after head injury.
OBJECTIVE: To study the hypothesis that concentrations of procollagen propeptides of type I and III collagens (PICP and PIIINP, respectively) and the carboxyterminal telopeptide of type I collagen (ICTP) in subdural haematoma increase in a time-dependent manner as a sign of dural collagen synthesis after head injury. METHODS: Thirty-six patients with subdural haematoma were operated. Subdural haematoma fluid samples were assayed for the concentrations of PICP, PIIINP and ICTP by specific radioimmunoassays. RESULTS: High concentrations of PICP, PIIINP and ICTP were found in subdural haematoma. The mean concentration of PICP in the 36 subdural haematoma samples was 11.8 (SD 9.27) mg/l, the concentration of PIIINP 590 (SD 302) microg/l and that of ICTP 32.0 (SD 12.1) microg/l. The time elapsed from the alleged head injury to operation could be defined in 30 patients. The concentrations of PICP, PIIINP and ICTP in subdural haematoma increased rapidly during the first two weeks after head injury and then stayed high for at least three months. CONCLUSIONS: High concentrations of procollagen propeptides were found in subdural haematoma samples of different haematoma age. Concentrations of these propeptides seem to follow a time-dependent course. The elevation of the concentrations of procollagen propeptides in subdural haematoma may be regarded as a sign of sustained dural collagen synthesis after head injury.
Authors: Tony L Yaksh; Kelly A Eddinger; Shinichi Kokubu; Zhenping Wang; Anna DiNardo; Roshni Ramachandran; Yuelian Zhu; Yajun He; Fieke Weren; Daphne Quang; Shelle A Malkmus; Katherine Lansu; Wesley K Kroeze; Brian Eliceiri; Joanne J Steinauer; Peter W Schiller; Peter Gmeiner; Linda M Page; Keith R Hildebrand Journal: Anesthesiology Date: 2019-07 Impact factor: 7.892
Authors: Ellie Edlmann; Susan Giorgi-Coll; Peter C Whitfield; Keri L H Carpenter; Peter J Hutchinson Journal: J Neuroinflammation Date: 2017-05-30 Impact factor: 8.322