Katherine A Halmi1. 1. Weill Cornell Medical College, 21 Bloomingdale Rd., White Plains, NY 10605, USA. kah29@cornell.edu
Abstract
BACKGROUND: Etiological hypotheses of eating disorders, anorexia nervosa and bulimia nervosa have not produced informative research for predictably effective treatment. METHODS: The rationale for applying a model of allostasis, a dysregulation of reward circuits with activation of brain and hormonal stress responses to maintain apparent stability, is developed for eating disorders. RESULTS: The neurotransmitter systems involved in the allostatic state of a reward system in anorexia nervosa and bulimia nervosa may be similar to those present in drug addiction. CONCLUSION: The biological vulnerabilities underlying the unique features of eating disorders should be intensively investigated with the advancing techniques in genetics and neuroimaging. Preventing chronicity with early diagnosis and adequate treatment before age 18 is necessary.
BACKGROUND: Etiological hypotheses of eating disorders, anorexia nervosa and bulimia nervosa have not produced informative research for predictably effective treatment. METHODS: The rationale for applying a model of allostasis, a dysregulation of reward circuits with activation of brain and hormonal stress responses to maintain apparent stability, is developed for eating disorders. RESULTS: The neurotransmitter systems involved in the allostatic state of a reward system in anorexia nervosa and bulimia nervosa may be similar to those present in drug addiction. CONCLUSION: The biological vulnerabilities underlying the unique features of eating disorders should be intensively investigated with the advancing techniques in genetics and neuroimaging. Preventing chronicity with early diagnosis and adequate treatment before age 18 is necessary.
Authors: D S Pisetsky; S E Trace; K A Brownley; R M Hamer; N L Zucker; P Roux-Lombard; J-M Dayer; C M Bulik Journal: Cytokine Date: 2014-06-14 Impact factor: 3.861
Authors: Guido K W Frank; Jeremy R Reynolds; Megan E Shott; Leah Jappe; Tony T Yang; Jason R Tregellas; Randall C O'Reilly Journal: Neuropsychopharmacology Date: 2012-05-02 Impact factor: 7.853
Authors: Katherine A Halmi; Dara Bellace; Samantha Berthod; Samiran Ghosh; Wade Berrettini; Harry A Brandt; Cynthia M Bulik; Steve Crawford; Manfred M Fichter; Craig L Johnson; Allan Kaplan; Walter H Kaye; Laura Thornton; Janet Treasure; D Blake Woodside; Michael Strober Journal: Int J Eat Disord Date: 2012-04-05 Impact factor: 4.861
Authors: Maggie M Sweitzer; Karli K Watson; Savannah R Erwin; Amy A Winecoff; Nandini Datta; Scott Huettel; Michael L Platt; Nancy L Zucker Journal: PLoS One Date: 2018-12-04 Impact factor: 3.240