OBJECTIVES: To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes. DESIGN: Multisite randomized controlled double-blind trial with two treatment groups. SETTING:Communities in northern and southern California and Minnesota. PARTICIPANTS: Community-dwelling adults aged 65 and older (N=487) without a diagnosis of clinically significant cognitive impairment. INTERVENTION: Participants were randomized to receive a broadly-available brain plasticity-based computerized cognitive training program (intervention) or a novelty- and intensity-matched general cognitive stimulation program modeling treatment as usual (active control). Duration of training was 1 hour per day, 5 days per week, for 8 weeks, for a total of 40 hours. MEASUREMENTS: The primary outcome was a composite score calculated from six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status that use the auditory modality (RBANS Auditory Memory/Attention). Secondary measures were derived from performance on the experimental program, standardized neuropsychological assessments of memory and attention, and participant-reported outcomes. RESULTS:RBANS Auditory Memory/Attention improvement was significantly greater (P=.02) in the experimental group (3.9 points, 95% confidence interval (CI)=2.7-5.1) than in the control group (1.8 points, 95% CI=0.6-3.0). Multiple secondary measures of memory and attention showed significantly greater improvements in the experimental group (word list total score, word list delayed recall, digits backwards, letter-number sequencing; P<.05), as did the participant-reported outcome measure (P=.001). No advantage for the experimental group was seen in narrative memory. CONCLUSION: The experimental program improved generalized measures of memory and attention more than an active control program.
RCT Entities:
OBJECTIVES: To investigate the efficacy of a novel brain plasticity-based computerized cognitive training program in older adults and to evaluate the effect on untrained measures of memory and attention and participant-reported outcomes. DESIGN: Multisite randomized controlled double-blind trial with two treatment groups. SETTING: Communities in northern and southern California and Minnesota. PARTICIPANTS: Community-dwelling adults aged 65 and older (N=487) without a diagnosis of clinically significant cognitive impairment. INTERVENTION: Participants were randomized to receive a broadly-available brain plasticity-based computerized cognitive training program (intervention) or a novelty- and intensity-matched general cognitive stimulation program modeling treatment as usual (active control). Duration of training was 1 hour per day, 5 days per week, for 8 weeks, for a total of 40 hours. MEASUREMENTS: The primary outcome was a composite score calculated from six subtests of the Repeatable Battery for the Assessment of Neuropsychological Status that use the auditory modality (RBANS Auditory Memory/Attention). Secondary measures were derived from performance on the experimental program, standardized neuropsychological assessments of memory and attention, and participant-reported outcomes. RESULTS: RBANS Auditory Memory/Attention improvement was significantly greater (P=.02) in the experimental group (3.9 points, 95% confidence interval (CI)=2.7-5.1) than in the control group (1.8 points, 95% CI=0.6-3.0). Multiple secondary measures of memory and attention showed significantly greater improvements in the experimental group (word list total score, word list delayed recall, digits backwards, letter-number sequencing; P<.05), as did the participant-reported outcome measure (P=.001). No advantage for the experimental group was seen in narrative memory. CONCLUSION: The experimental program improved generalized measures of memory and attention more than an active control program.
Authors: Jerri D Edwards; Virginia G Wadley; R enee S Myers; Daniel L Roenker; Gayla M Cissell; Karlene K Ball Journal: Gerontology Date: 2002 Sep-Oct Impact factor: 5.140
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Authors: R S Wilson; D A Bennett; J L Bienias; N T Aggarwal; C F Mendes De Leon; M C Morris; J A Schneider; D A Evans Journal: Neurology Date: 2002-12-24 Impact factor: 9.910
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Authors: Kristine Yaffe; Patrick Fox; Robert Newcomer; Laura Sands; Karla Lindquist; Kyle Dane; Kenneth E Covinsky Journal: JAMA Date: 2002-04-24 Impact factor: 56.272
Authors: Howard M Fillit; Robert N Butler; Alan W O'Connell; Marilyn S Albert; James E Birren; Carl W Cotman; William T Greenough; Paul E Gold; Arthur F Kramer; Lewis H Kuller; Thomas T Perls; Barbara G Sahagan; Tim Tully Journal: Mayo Clin Proc Date: 2002-07 Impact factor: 7.616
Authors: Susan J Pressler; Barbara Therrien; Penny L Riley; Cheng-Chen Chou; David L Ronis; Todd M Koelling; Dean G Smith; Barbara Jean Sullivan; Ann-Marie Frankini; Bruno Giordani Journal: J Card Fail Date: 2011-10 Impact factor: 5.712
Authors: Dona E C Locke; Cynthia M Stonnington; Michael L Thomas; Richard J Caselli Journal: J Clin Exp Neuropsychol Date: 2011-06-27 Impact factor: 2.475
Authors: Cornelia Beck; Jennifer Kleiner Fausett; Rebecca A Krukowski; Carol E Cornell; T Elaine Prewitt; Shelly Lensing; Zoran Bursac; Holly C Felix; ShaRhonda Love; Graham McDougall; Delia Smith West Journal: J Aging Health Date: 2012-12-16