BACKGROUND AND PURPOSE: It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An increased frequency of WHMs has been described in primary Sjögren's syndrome (PSS), but no controlled studies exist. The aim of this study was therefore to compare WMHs in PSS patients and healthy subjects applying the new European-American criteria for PSS. METHODS: Cross-sectional controlled study of 68 unselected PSS patients and 68 healthy subjects was carried out. WMHs were rated using Scheltens method. RESULTS: There were no differences in total or any regional WMH scores between PSS patients and healthy subjects. CONCLUSIONS: Patients with PSS do not have increased WMH load or distribution when compared with healthy subjects.
BACKGROUND AND PURPOSE: It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An increased frequency of WHMs has been described in primary Sjögren's syndrome (PSS), but no controlled studies exist. The aim of this study was therefore to compare WMHs in PSSpatients and healthy subjects applying the new European-American criteria for PSS. METHODS: Cross-sectional controlled study of 68 unselected PSSpatients and 68 healthy subjects was carried out. WMHs were rated using Scheltens method. RESULTS: There were no differences in total or any regional WMH scores between PSSpatients and healthy subjects. CONCLUSIONS:Patients with PSS do not have increased WMH load or distribution when compared with healthy subjects.
Authors: Maria Boge Lauvsnes; Henrik Zetterberg; Kaj Blennow; Jan Terje Kvaløy; Anne Bolette Tjensvoll; Stian Maroni; Mona K Beyer; Ole Jacob Greve; Ingeborg Kvivik; Guido Alves; Lasse Gunnar Gøransson; Erna Harboe; Shunsei Hirohata; Roald Omdal Journal: J Neurol Date: 2021-11-20 Impact factor: 4.849
Authors: L C Tzarouchi; A K Zikou; N Tsifetaki; L G Astrakas; S Konitsiotis; P Voulgari; A Drosos; M I Argyropoulou Journal: AJNR Am J Neuroradiol Date: 2013-11-01 Impact factor: 3.825
Authors: Solveig K Hammonds; Maria B Lauvsnes; Ingvild Dalen; Mona K Beyer; Kathinka D Kurz; Ole J Greve; Katrine B Norheim; Roald Omdal Journal: Rheumatol Adv Pract Date: 2017-10-17
Authors: Frederic Blanc; Nadine Longato; Barbara Jung; Catherine Kleitz; Laure Di Bitonto; Benjamin Cretin; Nicolas Collongues; Christelle Sordet; Marie Fleury; Vincent Poindron; Jacques-Eric Gottenberg; Olivier Anne; Dan Lipsker; Thierry Martin; Jean Sibilia; Jérôme de Seze Journal: ISRN Neurol Date: 2013-09-19