Literature DB >> 1922000

Glucocorticoid regulation of rRNA synthesis.

P B Mahajan1, E A Thompson.   

Abstract

Glucocorticoids inhibit transcription of the genes encoding rRNA (rDNA) in P1798 lymphoma cells. This is due to a decrease in the amount or activity of a transcription factor, called TFIC. TFIC has been purified to apparent homogeneity and the properties of this protein have been investigated in detail. TFIC is tightly associated with RNA polymerase I. The data indicate that TFIC is a bona fide initiation factor that is required for formation of the first phosphodiester bond of nascent pre-rRNA. Extracts from dexamethasone-treated cells are devoid of this factor and cannot form initiated complexes in vitro.

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Year:  1991        PMID： 1922000     DOI： 10.1007/bf00229820

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  13 in total

1.  Hormonal regulation of transcription of rDNA. Purification and characterization of the hormone-regulated transcription factor IC.

Authors:  P B Mahajan; E A Thompson
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

2.  Hormonal regulation of transcription of rDNA. Formation of initiated complexes by RNA polymerase I in vitro.

Authors:  P K Gokal; P B Mahajan; E A Thompson
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

3.  Hormonal regulation of transcription of rDNA. The role of TFIC in formation of initiation complexes.

Authors:  P B Mahajan; P K Gokal; E A Thompson
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

4.  Glucocorticoids selectively inhibit translation of ribosomal protein mRNAs in P1798 lymphosarcoma cells.

Authors:  O Meyuhas; E A Thompson; R P Perry
Journal:  Mol Cell Biol       Date:  1987-08       Impact factor: 4.272

5.  Specific transcription of mouse ribosomal DNA in a cell-free system that mimics control in vivo.

Authors:  I Grummt
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

6.  Glucocorticoid inhibition of initiation of transcription of the DNA encoding rRNA (rDNA) in lymphosarcoma P1798 cells.

Authors:  A H Cavanaugh; P K Gokal; R P Lawther; E A Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1984-02       Impact factor: 11.205

7.  Hormonal regulation of transcription of rDNA: glucocorticoid effects upon initiation and elongation in vitro.

Authors:  A H Cavanaugh; E A Thompson
Journal:  Nucleic Acids Res       Date:  1985-05-10       Impact factor: 16.971

8.  Hormonal regulation of transcription of rDNA. Initiation of transcription by RNA polymerase I in vitro.

Authors:  A H Cavanaugh; E A Thompson
Journal:  J Biol Chem       Date:  1986-09-25       Impact factor: 5.157

9.  Fractionation and reconstitution of factors required for accurate transcription of mammalian ribosomal RNA genes: identification of a species-dependent initiation factor.

Authors:  Y Mishima; I Financsek; R Kominami; M Muramatsu
Journal:  Nucleic Acids Res       Date:  1982-11-11       Impact factor: 16.971

10.  Hormonal regulation of transcription of rDNA. Inhibition of transcription during glucocorticoid-mediated inhibition of proliferation of lymphosarcoma P1798 cells in culture.

Authors:  A H Cavannaugh; E A Thompson
Journal:  J Biol Chem       Date:  1983-08-25       Impact factor: 5.157
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  2 in total

Review 1.  Regulation of adrenocorticosteroid receptor mRNA expression in the central nervous system.

Authors:  J P Herman
Journal:  Cell Mol Neurobiol       Date:  1993-08       Impact factor: 5.046

2.  Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription.

Authors:  Kazuo Yamamoto; Mika Yamamoto; Ken-ichi Hanada; Yasuhisa Nogi; Toshifumi Matsuyama; Masami Muramatsu
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272
  2 in total

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