Literature DB >> 19219417

[31-year-old male patient with testicular mass and hyperthyroidism].

B Besemer1, K Mann, M Horger, K Müssig.   

Abstract

An excess of human chorionic gonadotropin (hCG) is a rare differential diagnosis of hyperthyroidism, due to the TSH-like effect of hCG. hCG levels physiologically increase during pregnancy. In patients with germ cell tumors of the testicles and the ovary, a pathological increase of hCG serum concentrations may also be found, depending on the histological subtype. We report on a 31-year-old male patient with overt clinical hyperthyroidism resulting of a hCG-producing metastasized germ cell tumor of the right testicle. After initiation of chemotherapy, thyroid function normalized in parallel to the tumor's remission with marked decrease of hCG levels.

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Year:  2009        PMID: 19219417     DOI: 10.1007/s00108-008-2281-y

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN: 0020-9554            Impact factor:   0.743


  19 in total

1.  Thyrotoxicosis from molar thyrotropin.

Authors:  P J Karp; J M Hershman; S Richmond; D P Goldstein; H A Selenkow
Journal:  Arch Intern Med       Date:  1973-09

Review 2.  Thyrotoxicosis in a male patient associated with excess human chorionic gonadotropin production by germ cell tumor.

Authors:  M O Goodarzi; A J Van Herle
Journal:  Thyroid       Date:  2000-07       Impact factor: 6.568

3.  Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors.

Authors:  K Mann; N Schneider; R Hoermann
Journal:  Endocrinology       Date:  1986-04       Impact factor: 4.736

4.  Choriogonadotropin-mediated thyrotoxicosis in a man.

Authors:  H J Cain; P R Pannall; D Kotasek; R J Norman
Journal:  Clin Chem       Date:  1991-06       Impact factor: 8.327

5.  Does tumor-derived human chorionic gonadotropin act as a thyroid stimulator in vivo?

Authors:  S Madersbacher; S Schwarz; K Mann; R Klieber; G Wick; P Berger
Journal:  Clin Chem       Date:  1993-02       Impact factor: 8.327

6.  Hyperthyroidism in men with germ cell tumors and high levels of beta-human chorionic gonadotropin.

Authors:  S A Giralt; F Dexeus; R Amato; A Sella; C Logothetis
Journal:  Cancer       Date:  1992-03-01       Impact factor: 6.860

Review 7.  Metastatic testicular choriocarcinoma and secondary hyperthyroidism: case report and review of the literature.

Authors:  P E Gleason; D S Elliott; D Zimmerman; W A Smithson; S A Kramer
Journal:  J Urol       Date:  1994-04       Impact factor: 7.450

Review 8.  Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid.

Authors:  Jerome M Hershman
Journal:  Best Pract Res Clin Endocrinol Metab       Date:  2004-06       Impact factor: 4.690

Review 9.  Human chorionic gonadotropin-induced hyperthyroidism in germ cell cancer--a case presentation and review of the literature.

Authors:  Wieland Voigt; Gita Maher; Hans-Heinrich Wolf; Hans-Joachim Schmoll
Journal:  Onkologie       Date:  2007-06

10.  [Hyperthyroidism caused by metastatic choriocarcinoma. A new male case].

Authors:  R Maréchaud; M Vabre; Y Sudre; D Bontoux
Journal:  Ann Med Interne (Paris)       Date:  1985
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