Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Who and where is the renal baroreceptor?: the connexin hypothesis.

Literature DB >> 19219002

Who and where is the renal baroreceptor?: the connexin hypothesis.

R Ariel Gomez¹, Maria Luisa S Sequeira Lopez.

Abstract

Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19219002 PMCID： PMC3025775 DOI： 10.1038/ki.2008.536

Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612

14 in total

1. The effect of high perfusion pressures on the granulation of juxtaglomerular cells in an isolated kidney.

Authors: L TOBIAN; A TOMBOULIAN; J JANECEK
Journal: J Clin Invest Date: 1959-04 Impact factor: 14.808

2. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.

Authors: Maria Luisa S Sequeira López; Ellen S Pentz; Takayo Nomasa; Oliver Smithies; R Ariel Gomez
Journal: Dev Cell Date: 2004-05 Impact factor: 12.270

3. Kidney function in mice lacking aldosterone.

Authors: Natalia Makhanova; Gene Lee; Nobuyuki Takahashi; Maria L Sequeira Lopez; R Ariel Gomez; Hyung-Suk Kim; Oliver Smithies
Journal: Am J Physiol Renal Physiol Date: 2005-08-23

4. Connexin40 is essential for the pressure control of renin synthesis and secretion.

Authors: Charlotte Wagner; Cor de Wit; Lisa Kurtz; Christian Grünberger; Armin Kurtz; Frank Schweda
Journal: Circ Res Date: 2007-01-25 Impact factor: 17.367

Review 5. Pannexins and gap junction protein diversity.

Authors: V I Shestopalov; Y Panchin
Journal: Cell Mol Life Sci Date: 2008-02 Impact factor: 9.261

6. Expression and role of connexins in the rat renal vasculature.

Authors: T Takenaka; T Inoue; Y Kanno; H Okada; K R Meaney; C E Hill; H Suzuki
Journal: Kidney Int Date: 2007-11-28 Impact factor: 10.612

7. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme.

Authors: K F Hilgers; V Reddi; J H Krege; O Smithies; R A Gomez
Journal: Hypertension Date: 1997-01 Impact factor: 10.190

8. Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.

Authors: Lisa Kurtz; Frank Schweda; Cor de Wit; Wilhelm Kriz; Ralph Witzgall; Richard Warth; Alexander Sauter; Armin Kurtz; Charlotte Wagner
Journal: J Am Soc Nephrol Date: 2007-02-28 Impact factor: 10.121

9. Connexin43-dependent mechanism modulates renin secretion and hypertension.

Authors: Jacques-Antoine Haefliger; Nathalie Krattinger; David Martin; Thierry Pedrazzini; Alessandro Capponi; Britta Döring; Achim Plum; Anne Charollais; Klaus Willecke; Paolo Meda
Journal: J Clin Invest Date: 2006-01-26 Impact factor: 14.808

10. Connexin40 regulates renin production and blood pressure.

Authors: N Krattinger; A Capponi; L Mazzolai; J-F Aubert; D Caille; P Nicod; G Waeber; P Meda; J-A Haefliger
Journal: Kidney Int Date: 2007-07-11 Impact factor: 10.612

15 in total

Review 1. The renin phenotype: roles and regulation in the kidney.

Authors: Maria L S Sequeira Lopez; R Ariel Gomez
Journal: Curr Opin Nephrol Hypertens Date: 2010-07 Impact factor: 2.894

2. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

Authors: Ruth M Castellanos Rivera; Maria C Monteagudo; Ellen S Pentz; Sean T Glenn; Kenneth W Gross; Oscar Carretero; Maria Luisa S Sequeira-Lopez; R Ariel Gomez
Journal: Physiol Genomics Date: 2011-07-12 Impact factor: 3.107

3. Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.

Authors: Charlotte Wagner; Alexander Jobs; Frank Schweda; Lisa Kurtz; Birguel Kurt; Maria L Sequeira Lopez; R Ariel Gomez; Toon A B van Veen; Cor de Wit; Armin Kurtz
Journal: Kidney Int Date: 2010-08-04 Impact factor: 10.612

Who and where is the renal baroreceptor?: the connexin hypothesis.

1. The effect of high perfusion pressures on the granulation of juxtaglomerular cells in an isolated kidney.

2. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened.

3. Kidney function in mice lacking aldosterone.

4. Connexin40 is essential for the pressure control of renin synthesis and secretion.

Review 5. Pannexins and gap junction protein diversity.

6. Expression and role of connexins in the rat renal vasculature.

7. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme.

8. Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium.

9. Connexin43-dependent mechanism modulates renin secretion and hypertension.

10. Connexin40 regulates renin production and blood pressure.

Review 1. The renin phenotype: roles and regulation in the kidney.

2. Transcriptional regulator RBP-J regulates the number and plasticity of renin cells.

3. Selective deletion of Connexin 40 in renin-producing cells impairs renal baroreceptor function and is associated with arterial hypertension.

Review 4. Juxtaglomerular Cell Tumor: Reviewing a Cryptic Cause of Surgically Correctable Hypertension.

5. Sox6 as a new modulator of renin expression in the kidney.

Review 6. Novel mechanisms for the control of renin synthesis and release.

Review 7. Atherosclerotic renal artery stenosis--diagnosis and treatment.

Review 8. Renin cells in homeostasis, regeneration and immune defence mechanisms.

Review 9. Classical Renin-Angiotensin system in kidney physiology.

Review 10. Renin Cells, the Kidney, and Hypertension.