Literature DB >> 19217778

[18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain.

Kazuhiko Yanamoto1, Katsushi Kumata, Tomoteru Yamasaki, Chika Odawara, Kazunori Kawamura, Joji Yui, Akiko Hatori, Kazutoshi Suzuki, Ming-Rong Zhang.   

Abstract

[(18)F]FEAC ([(18)F]4a) and [(18)F]FEDAC ([(18)F]4b) were developed as two novel positron emission tomography (PET) ligands for peripheral-type benzodiazepine receptor (PBR). [(18)F]4a and [(18)F]4b were synthesized by fluoroethylation of precursors 8a and 8b with [(18)F]FCH(2)CH(2)Br ([(18)F]9), respectively. Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased.

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Year:  2009        PMID： 19217778     DOI： 10.1016/j.bmcl.2009.01.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.

Authors:  Jun Maeda; Ming-Rong Zhang; Takashi Okauchi; Bin Ji; Maiko Ono; Satoko Hattori; Katsushi Kumata; Nobuhisa Iwata; Takaomi C Saido; John Q Trojanowski; Virginia M-Y Lee; Matthias Staufenbiel; Takami Tomiyama; Hiroshi Mori; Toshimitsu Fukumura; Tetsuya Suhara; Makoto Higuchi
Journal:  J Neurosci       Date:  2011-03-23       Impact factor: 6.167

Review 2.  Novel PET Imaging of Inflammatory Targets and Cells for the Diagnosis and Monitoring of Giant Cell Arteritis and Polymyalgia Rheumatica.

Authors:  Kornelis S M van der Geest; Maria Sandovici; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Elisabeth Brouwer; William F Jiemy
Journal:  Front Med (Lausanne)       Date:  2022-06-06

3.  In vivo imaging of neuroinflammation: a comparative study between [(18)F]PBR111, [ (11)C]CLINME and [ (11)C]PK11195 in an acute rodent model.

Authors:  Nadja Van Camp; Raphael Boisgard; Bertrand Kuhnast; Benoit Thézé; Thomas Viel; Marie-Claude Grégoire; Fabien Chauveau; Hervé Boutin; Andrew Katsifis; Frédéric Dollé; Bertrand Tavitian
Journal:  Eur J Nucl Med Mol Imaging       Date:  2010-01-13       Impact factor: 9.236

Review 4.  Recent developments on PET radiotracers for TSPO and their applications in neuroimaging.

Authors:  Lingling Zhang; Kuan Hu; Tuo Shao; Lu Hou; Shaojuan Zhang; Weijian Ye; Lee Josephson; Jeffrey H Meyer; Ming-Rong Zhang; Neil Vasdev; Jinghao Wang; Hao Xu; Lu Wang; Steven H Liang
Journal:  Acta Pharm Sin B       Date:  2020-08-25       Impact factor: 11.413

5.  Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin.

Authors:  Takayuki Ohkubo; Yusuke Kurihara; Masanao Ogawa; Nobuki Nengaki; Masayuki Fujinaga; Wakana Mori; Katsushi Kumata; Masayuki Hanyu; Kenji Furutsuka; Hiroki Hashimoto; Kazunori Kawamura; Ming-Rong Zhang
Journal:  EJNMMI Radiopharm Chem       Date:  2021-07-10

6.  PET imaging of lung inflammation with [18F]FEDAC, a radioligand for translocator protein (18 kDa).

Authors:  Akiko Hatori; Joji Yui; Tomoteru Yamasaki; Lin Xie; Katsushi Kumata; Masayuki Fujinaga; Yuichiro Yoshida; Masanao Ogawa; Nobuki Nengaki; Kazunori Kawamura; Toshimitsu Fukumura; Ming-Rong Zhang
Journal:  PLoS One       Date:  2012-09-12       Impact factor: 3.240

7.  Radiopharmaceutical tracers for cardiac imaging.

Authors:  Osamu Manabe; Tatsuya Kikuchi; Arthur J H A Scholte; Mohammed El Mahdiui; Ryuichi Nishii; Ming-Rong Zhang; Eriko Suzuki; Keiichiro Yoshinaga
Journal:  J Nucl Cardiol       Date:  2017-12-01       Impact factor: 5.952

8.  In vivo monitoring of remnant undifferentiated neural cells following human induced pluripotent stem cell-derived neural stem/progenitor cells transplantation.

Authors:  Yuji Tanimoto; Tomoteru Yamasaki; Narihito Nagoshi; Yuichiro Nishiyama; Satoshi Nori; Soraya Nishimura; Tsuyoshi Iida; Masahiro Ozaki; Osahiko Tsuji; Bin Ji; Ichio Aoki; Masahiro Jinzaki; Morio Matsumoto; Yasuhisa Fujibayashi; Ming-Rong Zhang; Masaya Nakamura; Hideyuki Okano
Journal:  Stem Cells Transl Med       Date:  2020-01-06       Impact factor: 6.940
  8 in total

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