| Literature DB >> 19217710 |
Yesennia Sánchez-Pérez1, Yolanda I Chirino2, Álvaro R Osornio-Vargas2, Rocío Morales-Bárcenas2, Concepción Gutiérrez-Ruíz3, Inés Vázquez-López2, Claudia M García-Cuellar4.
Abstract
We describe the events triggered by a sub-lethal concentration of airborne particulate matter (PM(10)) in A549 cells, which include the formation DNA double-strand breaks, gammaH2A.X generation, and 53BP1 recruitment. To protect the genome, cells activated ATM/ATR/Chk1/Chk2/p53 pathway but, after 48 h, cells turned into a senescence-like state. Trolox, an antioxidant, was able to prevent most of the alterations observed after particulate matter exposure, demonstrating the important role of ROS as mediator of PM(10)-induced genotoxicity and suggesting that DNA damage could be the mechanisms by which particulate matter augment the risk of lung cancer.Entities:
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Year: 2009 PMID： 19217710 DOI： 10.1016/j.canlet.2009.01.010
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679