Literature DB >> 19217699

Synthesis and biological evaluation of abietic acid derivatives.

Miguel A González1, Julieth Correa-Royero, Lee Agudelo, Ana Mesa, Liliana Betancur-Galvis.   

Abstract

A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.

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Year:  2009        PMID： 19217699     DOI： 10.1016/j.ejmech.2009.01.014

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

1.  High-Throughput 1H-Nuclear Magnetic Resonance-Based Screening for the Identification and Quantification of Heartwood Diterpenic Acids in Four Black Pine (Pinus nigra Arn.) Marginal Provenances in Greece.

Authors:  Kostas Ioannidis; Eleni Melliou; Prokopios Magiatis
Journal:  Molecules       Date:  2019-10-07       Impact factor: 4.411

2.  Growth Inhibition and Apoptotic Effect of Pine Extract and Abietic Acid on MCF-7 Breast Cancer Cells via Alteration of Multiple Gene Expressions Using In Vitro Approach.

Authors:  Hesham Haffez; Shimaa Osman; Hassan Y Ebrahim; Zeinab A Hassan
Journal:  Molecules       Date:  2022-01-04       Impact factor: 4.411

3.  Semisynthetic Abietic and Dehydroabietic Acid Derivatives and Triptoquinone Epimers Interfere with LPS-Triggered Activation of Dendritic Cells.

Authors:  Jelver A Sierra; Katherine Gilchrist; Jorge H Tabares-Guevara; Liliana Betancur-Galvis; Jose R Ramirez-Pineda; Miguel A González-Cardenete
Journal:  Molecules       Date:  2022-10-08       Impact factor: 4.927

4.  The conifer biomarkers dehydroabietic and abietic acids are widespread in Cyanobacteria.

Authors:  Maria Sofia Costa; Adriana Rego; Vitor Ramos; Tiago B Afonso; Sara Freitas; Marco Preto; Viviana Lopes; Vitor Vasconcelos; Catarina Magalhães; Pedro N Leão
Journal:  Sci Rep       Date:  2016-03-21       Impact factor: 4.379

5.  Hepatoprotective and Cytotoxic Activities of Abietic Acid from Isodon wightii (Bentham) H. Hara.

Authors:  Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan; Sadasivam Mathusalini; Palathurai Subramanium Mohan
Journal:  Pharmacognosy Res       Date:  2016 Jul-Sep

6.  Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy.

Authors:  Lingling Yang; Feng Chen; Cheng Gao; Jiabao Chen; Junyan Li; Siyan Liu; Yuanyuan Zhang; Zhouyu Wang; Shan Qian
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051
  6 in total

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