OBJECTIVE: The purpose of this study was to predict the occurrence of preeclampsia in a series of patients at gestational week 15-20 weeks, with the use of a panel of messenger RNA markers. STUDY DESIGN: Data from 62 patients with preeclampsia who were asymptomatic at the time of blood testing and 310 control subjects were analyzed. Multivariable analysis was performed with discriminant analysis. RESULTS: Univariable analysis identified vascular endothelial growth factor receptor 1 as the marker with the highest detection rate; placenta-specific 1 with the lowest. Mean estimated score for preeclampsia was 9.4 for control subjects and 72.5 for subjects who experienced preeclampsia. A receiver operating characteristic curve that was obtained with the estimated score for preeclampsia as a test variable yielded a detection rate of 84% (95% CI, 71.8-91.5) at a 5% false-positive rate with an area under the curve of 0.927 (P < .001). Again, detection rate and score for each patient for classification as preeclamptic correlated with severity. CONCLUSION: A panel of messenger RNA is able to detect subjects who will experience preeclampsia.
OBJECTIVE: The purpose of this study was to predict the occurrence of preeclampsia in a series of patients at gestational week 15-20 weeks, with the use of a panel of messenger RNA markers. STUDY DESIGN: Data from 62 patients with preeclampsia who were asymptomatic at the time of blood testing and 310 control subjects were analyzed. Multivariable analysis was performed with discriminant analysis. RESULTS: Univariable analysis identified vascular endothelial growth factor receptor 1 as the marker with the highest detection rate; placenta-specific 1 with the lowest. Mean estimated score for preeclampsia was 9.4 for control subjects and 72.5 for subjects who experienced preeclampsia. A receiver operating characteristic curve that was obtained with the estimated score for preeclampsia as a test variable yielded a detection rate of 84% (95% CI, 71.8-91.5) at a 5% false-positive rate with an area under the curve of 0.927 (P < .001). Again, detection rate and score for each patient for classification as preeclamptic correlated with severity. CONCLUSION: A panel of messenger RNA is able to detect subjects who will experience preeclampsia.
Authors: Nándor Gábor Than; Máté Posta; Dániel Györffy; László Orosz; Gergő Orosz; Simona W Rossi; Géza Ambrus-Aikelin; András Szilágyi; Sándor Nagy; Petronella Hupuczi; Olga Török; Adi L Tarca; Offer Erez; Zoltán Papp; Roberto Romero Journal: Placenta Date: 2022-03-22 Impact factor: 3.287
Authors: Osnat Ashur-Fabian; Gil M Yerushalmi; Shali Mazaki-Tovi; David M Steinberg; Inbal Goldshtein; Michal Yackobovitch-Gavan; Eyal Schiff; Ninette Amariglio; Gideon Rechavi Journal: PLoS One Date: 2012-05-16 Impact factor: 3.240