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Literature DB >> 19217513

Lowering low-density lipoprotein cholesterol: statins, ezetimibe, bile acid sequestrants, and combinations: comparative efficacy and safety.

Abstract

Statins, ezetimibe, and bile acid-binding resins can be used individually or in combination for lowering low-density lipoprotein cholesterol (LDL-C) levels. Statins are the most potent drugs for lowering LDL-C and are well tolerated in most patients. The addition of a bile acid sequestrant or ezetimibe to a statin produces additional LDL-C reduction allowing many patients to reach LDL-C targets. This article discusses the efficacy and safety of available statins, bile acid sequestrants, and ezetimibe in the treatment of hyperlipidemia.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19217513 DOI： 10.1016/j.ecl.2008.11.007

Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN： 0889-8529 Impact factor: 4.741

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Cited

27 in total

Review 1. Targets for current pharmacologic therapy in cholesterol gallstone disease.

Authors: Agostino Di Ciaula; David Q H Wang; Helen H Wang; Leonilde Bonfrate; Piero Portincasa
Journal: Gastroenterol Clin North Am Date: 2010-06 Impact factor: 3.806

Review 2. Consensus statement on management of dyslipidemia in Indian subjects.

Authors: K Sarat Chandra; Manish Bansal; Tiny Nair; S S Iyengar; Rajeev Gupta; Subhash C Manchanda; P P Mohanan; V Dayasagar Rao; C N Manjunath; J P S Sawhney; Nakul Sinha; A K Pancholia; Sundeep Mishra; Ravi R Kasliwal; Saumitra Kumar; Unni Krishnan; Sanjay Kalra; Anoop Misra; Usha Shrivastava; Seema Gulati
Journal: Indian Heart J Date: 2014-12-24

3. The case for more intensive use of statins.

Authors: Jordan Fulcher; Anthony Keech
Journal: Ther Adv Chronic Dis Date: 2012-09 Impact factor: 5.091

Review 4. From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport.

Authors: Alberto Dávalos; Carlos Fernández-Hernando
Journal: Pharmacol Res Date: 2013-02-19 Impact factor: 7.658

5. Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique.

Authors: Patrícia V Mendonça; André Matos; Andreia F Sousa; Arménio C Serra; Sérgio Simões; Jorge F J Coelho
Journal: Pharm Res Date: 2017-06-16 Impact factor: 4.200

Lowering low-density lipoprotein cholesterol: statins, ezetimibe, bile acid sequestrants, and combinations: comparative efficacy and safety.

Review 1. Targets for current pharmacologic therapy in cholesterol gallstone disease.

Review 2. Consensus statement on management of dyslipidemia in Indian subjects.

3. The case for more intensive use of statins.

Review 4. From evolution to revolution: miRNAs as pharmacological targets for modulating cholesterol efflux and reverse cholesterol transport.

5. Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique.

Review 6. Current Treatment of Familial Hypercholesterolaemia.

Review 7. Development of apolipoprotein B antisense molecules as a therapy for hyperlipidemia.

Review 8. Pharmacotherapies for lipid modification: beyond the statins.

9. Fish oil and indomethacin in combination potently reduce dyslipidemia and hepatic steatosis in LDLR(-/-) mice.

Review 10. Antilipidemic Drug Therapy Today and in the Future.