| Literature DB >> 19217419 |
Abstract
In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.Entities:
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Year: 2009 PMID： 19217419 DOI： 10.1016/j.devcel.2009.01.017
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270