Literature DB >> 19217418

A new G(q)-initiated MAPK signaling pathway in the heart.

J Silvio Gutkind, Stefan Offermanns.   

Abstract

Pathological cardiac hypertrophy involves auto/paracrine mediators acting through G(q/11)-coupled receptors. A novel signaling route stimulated by betagamma-subunits of G(q/11) results in the autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby activating hypertrophic gene programs.

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Year:  2009        PMID： 19217418     DOI： 10.1016/j.devcel.2009.01.021

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  9 in total

1.  On the selectivity of the Gαq inhibitor UBO-QIC: A comparison with the Gαi inhibitor pertussis toxin.

Authors:  Zhan-Guo Gao; Kenneth A Jacobson
Journal:  Biochem Pharmacol       Date:  2016-03-05       Impact factor: 5.858

Review 2.  Signaling effectors underlying pathologic growth and remodeling of the heart.

Authors:  Jop H van Berlo; Marjorie Maillet; Jeffery D Molkentin
Journal:  J Clin Invest       Date:  2013-01-02       Impact factor: 14.808

3.  Reactivation of fatty acid oxidation by medium chain fatty acid prevents myocyte hypertrophy in H9c2 cell line.

Authors:  Saifudeen Ismael; R Renuka Nair
Journal:  Mol Cell Biochem       Date:  2020-09-30       Impact factor: 3.396

4.  Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.

Authors:  Maren Kleine-Brueggeney; Irina Gradinaru; Ekaterina Babaeva; Debra A Schwinn; Anush Oganesian
Journal:  Cell Signal       Date:  2014-05-15       Impact factor: 4.315

Review 5.  Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.

Authors:  Valentina Sala; Simona Gallo; Christian Leo; Stefano Gatti; Bruce D Gelb; Tiziana Crepaldi
Journal:  Mol Med       Date:  2012-09-07       Impact factor: 6.354

6.  PEG-coated gold nanoparticles attenuate β-adrenergic receptor-mediated cardiac hypertrophy.

Authors:  Yuhui Qiao; Baoling Zhu; Aiju Tian; Zijian Li
Journal:  Int J Nanomedicine       Date:  2017-07-03

7.  Machine Learning Revealed Ferroptosis Features and a Novel Ferroptosis-Based Classification for Diagnosis in Acute Myocardial Infarction.

Authors:  Dan Huang; Shiya Zheng; Zhuyuan Liu; Kongbo Zhu; Hong Zhi; Genshan Ma
Journal:  Front Genet       Date:  2022-01-25       Impact factor: 4.599

Review 8.  Gq-Coupled Receptors in Autoimmunity.

Authors:  Lu Zhang; Guixiu Shi
Journal:  J Immunol Res       Date:  2016-01-17       Impact factor: 4.818

9.  The Selective Serotonin 2A Receptor Antagonist Sarpogrelate Prevents Cardiac Hypertrophy and Systolic Dysfunction via Inhibition of the ERK1/2-GATA4 Signaling Pathway.

Authors:  Kana Shimizu; Yoichi Sunagawa; Masafumi Funamoto; Hiroki Honda; Yasufumi Katanasaka; Noriyuki Murai; Yuto Kawase; Yuta Hirako; Takahiro Katagiri; Harumi Yabe; Satoshi Shimizu; Nurmila Sari; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto
Journal:  Pharmaceuticals (Basel)       Date:  2021-12-05
  9 in total

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