Literature DB >> 19217303

Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT.

Veronica Esposito1, Antonella Virgilio, Antonietta Pepe, Giorgia Oliviero, Luciano Mayol, Aldo Galeone.   

Abstract

Insight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.

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Year:  2009        PMID： 19217303     DOI： 10.1016/j.bmc.2009.01.027

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

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  9 in total

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