BACKGROUND: It is unknown whether interleukin-18 (IL-18) participates in the pathophysiology of nonrheumatic aortic stenosis (NR-AS). METHODS: We examined IL-18 expression in human NR-AS valves by immunohistochemistry and Western blot analysis. RESULTS: Immunohistochemistry revealed that NR-AS valves showed increased IL-18 expression compared with controls. IL-18 receptor was also expressed in NR-AS valves. Western blot analysis showed that IL-18 was expressed as an active form in NR-AS valves. Furthermore, increased IL-18 expression was correlated with the advanced clinical severity of NR-AS. CONCLUSIONS: IL-18 was expressed in the aortic valves and up-regulated in NR-AS valves. IL-18 may contribute to the pathophysiology of NR-AS.
BACKGROUND: It is unknown whether interleukin-18 (IL-18) participates in the pathophysiology of nonrheumatic aortic stenosis (NR-AS). METHODS: We examined IL-18 expression in human NR-AS valves by immunohistochemistry and Western blot analysis. RESULTS: Immunohistochemistry revealed that NR-AS valves showed increased IL-18 expression compared with controls. IL-18 receptor was also expressed in NR-AS valves. Western blot analysis showed that IL-18 was expressed as an active form in NR-AS valves. Furthermore, increased IL-18 expression was correlated with the advanced clinical severity of NR-AS. CONCLUSIONS:IL-18 was expressed in the aortic valves and up-regulated in NR-AS valves. IL-18 may contribute to the pathophysiology of NR-AS.
Authors: Vishal Patel; Katrina Carrion; Andrew Hollands; Andrew Hinton; Thomas Gallegos; Jeffrey Dyo; Roman Sasik; Emma Leire; Gary Hardiman; Salah A Mohamed; Sanjay Nigam; Charles C King; Victor Nizet; Vishal Nigam Journal: FASEB J Date: 2015-01-28 Impact factor: 5.191
Authors: Katrina Carrion; Jeffrey Dyo; Vishal Patel; Roman Sasik; Salah A Mohamed; Gary Hardiman; Vishal Nigam Journal: PLoS One Date: 2014-05-01 Impact factor: 3.240