AIMS: We aimed at quantifying acute axonal injury in victims of bacterial meningitis. METHODS: The brains of 26 autopsies with bacterial meningitis and of 10 control cases were studied by histology and quantitative immunohistochemistry for amyloid-beta precursor protein (APP). RESULTS: Mild to severe axonal injury in the white matter was present in 25 of 26 victims of meningitis. The area of axonal damage ranged from 0.0% to 1.38% (median = 0.08%, mean = 0.36%) of the total area studied in each individual case. In 4 of 10 age- and sex-matched control brains small areas also stained for APP (p = 0.0007). Axonal injury in meningitis was most prominent in the basal ganglia and pons, followed by the hippocampal formation, neocortex and the cervical spinal cord. The cerebellum was least affected. CONCLUSION: Axonal injury is a frequent complication of bacterial meningitis probably contributing to long-term sequelae in survivors.
AIMS: We aimed at quantifying acute axonal injury in victims of bacterial meningitis. METHODS: The brains of 26 autopsies with bacterial meningitis and of 10 control cases were studied by histology and quantitative immunohistochemistry for amyloid-beta precursor protein (APP). RESULTS: Mild to severe axonal injury in the white matter was present in 25 of 26 victims of meningitis. The area of axonal damage ranged from 0.0% to 1.38% (median = 0.08%, mean = 0.36%) of the total area studied in each individual case. In 4 of 10 age- and sex-matched control brains small areas also stained for APP (p = 0.0007). Axonal injury in meningitis was most prominent in the basal ganglia and pons, followed by the hippocampal formation, neocortex and the cervical spinal cord. The cerebellum was least affected. CONCLUSION:Axonal injury is a frequent complication of bacterial meningitis probably contributing to long-term sequelae in survivors.
Authors: Chi Ho Wai; Jessica Jin; Marek Cyrklaff; Christel Genoud; Charlotta Funaya; Julia Sattler; Aleksandra Maceski; Stephanie Meier; Sabine Heiland; Michael Lanzer; Friedrich Frischknecht; Jens Kuhle; Martin Bendszus; Angelika Hoffmann Journal: Sci Rep Date: 2022-06-24 Impact factor: 4.996
Authors: Geidy E Serrano; Jessica E Walker; Richard Arce; Michael J Glass; Daisy Vargas; Lucia I Sue; Anthony J Intorcia; Courtney M Nelson; Javon Oliver; Jaclyn Papa; Aryck Russell; Katsuko E Suszczewicz; Claryssa I Borja; Christine Belden; Danielle Goldfarb; David Shprecher; Alireza Atri; Charles H Adler; Holly A Shill; Erika Driver-Dunckley; Shyamal H Mehta; Benjamin Readhead; Matthew J Huentelman; Joseph L Peters; Ellie Alevritis; Christian Bimi; Joseph P Mizgerd; Eric M Reiman; Thomas J Montine; Marc Desforges; James L Zehnder; Malaya K Sahoo; Haiyu Zhang; Daniel Solis; Benjamin A Pinsky; Michael Deture; Dennis W Dickson; Thomas G Beach Journal: medRxiv Date: 2021-02-18