Literature DB >> 19216077

Microbial biotransformation as a source of chemical diversity in cane toad steroid toxins.

R Andrew Hayes1, Andrew M Piggott, Kristian Dalle, Robert J Capon.   

Abstract

The cane toad is an invasive pest that is rapidly colonising northern Australia. The cane toad parotoid gland secretes cardiotoxic steroids (bufadienolides) that are poisoning native predator species. This study reveals bufadienolide diversity within the secretions of Australian cane toads is different to cane toads from overseas, being far more structurally diverse than previously assumed. It is proposed that this variation is mediated by in situ bacterial biotransformation.

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Year:  2009        PMID： 19216077     DOI： 10.1016/j.bmcl.2009.01.064

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Identification of Bufadienolides from the Boreal Toad, Anaxyrus boreas, Active Against a Fungal Pathogen.

Authors:  Kelly Barnhart; Megan E Forman; Thomas P Umile; Jordan Kueneman; Valerie McKenzie; Irene Salinas; Kevin P C Minbiole; Douglas C Woodhams
Journal:  Microb Ecol       Date:  2017-06-19       Impact factor: 4.552

2.  Variation in Chemical Defense Among Natural Populations of Common Toad, Bufo bufo, Tadpoles: the Role of Environmental Factors.

Authors:  Veronika Bókony; Ágnes M Móricz; Zsófia Tóth; Zoltán Gál; Anikó Kurali; Zsanett Mikó; Katalin Pásztor; Márk Szederkényi; Zoltán Tóth; János Ujszegi; Bálint Üveges; Dániel Krüzselyi; Robert J Capon; Herbert Hoi; Attila Hettyey
Journal:  J Chem Ecol       Date:  2016-04-08       Impact factor: 2.626

Review 3.  A salamander's toxic arsenal: review of skin poison diversity and function in true salamanders, genus Salamandra.

Authors:  Tim Lüddecke; Stefan Schulz; Sebastian Steinfartz; Miguel Vences
Journal:  Naturwissenschaften       Date:  2018-09-04

Review 4.  A review of chemical defense in harlequin toads (Bufonidae: Atelopus).

Authors:  Kannon C Pearson; Rebecca D Tarvin
Journal:  Toxicon X       Date:  2022-01-22

Review 5.  Chemistry and the Potential Antiviral, Anticancer, and Anti-Inflammatory Activities of Cardiotonic Steroids Derived from Toads.

Authors:  Hesham R El-Seedi; Nermeen Yosri; Bishoy El-Aarag; Shaymaa H Mahmoud; Ahmed Zayed; Ming Du; Aamer Saeed; Syed G Musharraf; Islam M El-Garawani; Mohamed R Habib; Haroon Elrasheid Tahir; Momtaz M Hegab; Xiaobo Zou; Zhiming Guo; Thomas Efferth; Shaden A M Khalifa
Journal:  Molecules       Date:  2022-10-05       Impact factor: 4.927

6.  Exposure to Batrachochytrium dendrobatidis affects chemical defences in two anuran amphibians, Rana dalmatina and Bufo bufo.

Authors:  János Ujszegi; Krisztina Ludányi; Ágnes M Móricz; Dániel Krüzselyi; László Drahos; Tamás Drexler; Márk Z Németh; Judit Vörös; Trenton W J Garner; Attila Hettyey
Journal:  BMC Ecol Evol       Date:  2021-07-03

7.  Changes in Toxin Quantities Following Experimental Manipulation of Toxin Reserves in Bufo bufo Tadpoles.

Authors:  Zoltán Tóth; Anikó Kurali; Ágnes M Móricz; Attila Hettyey
Journal:  J Chem Ecol       Date:  2019-01-26       Impact factor: 2.626

8.  Relationships Between Chemical Defenses of Common Toad (Bufo bufo) Tadpoles and Bacterial Community Structure of their Natural Aquatic Habitat.

Authors:  János Ujszegi; Balázs Vajna; Ágnes M Móricz; Dániel Krüzselyi; Kristóf Korponai; Gergely Krett; Attila Hettyey
Journal:  J Chem Ecol       Date:  2020-05-28       Impact factor: 2.626
  8 in total

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