| Literature DB >> 19216075 |
Immacolata Conte1, Claudio Giuliano, Caterina Ercolani, Frank Narjes, Uwe Koch, Michael Rowley, Sergio Altamura, Raffaele De Francesco, Petra Neddermann, Giovanni Migliaccio, Ian Stansfield.
Abstract
The RNA replication machinery of HCV is a multi-subunit membrane-associated complex. NS5A has emerged as an active component of HCV replicase, possibly involved in regulation of viral replication and resistance to the antiviral effect of interferon. We report here substituted piperazinyl-N-(aryl)benzamides as potent inhibitors of HCV replication exerted via modulation of the dimerization of NS5A.Entities:
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Year: 2009 PMID： 19216075 DOI： 10.1016/j.bmcl.2009.01.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823