| Literature DB >> 19216074 |
Takeo Kasagami1, In-Hae Kim, Hsing-Ju Tsai, Kosuke Nishi, Bruce D Hammock, Christophe Morisseau.
Abstract
We investigated N-adamantyl-N'-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.Entities:
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Year: 2009 PMID： 19216074 PMCID： PMC2900318 DOI： 10.1016/j.bmcl.2009.01.069
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823