AIMS: To examine the hypothesis that increases in UK liver deaths are a result of episodic or binge drinking as opposed to regular harmful drinking. DESIGN: A prospective survey of consecutive in-patients and out-patients. SETTING: The liver unit of a teaching hospital in the South of England. PARTICIPANTS: A total of 234 consecutive in-patients and out-patients between October 2007 and March 2008. MEASUREMENTS: Face-to-face interviews, Alcohol Use Disorders Identification Test, 7-day drinking diary, Severity of Alcohol Dependence Questionnaire, Lifetime Drinking History and liver assessment. FINDINGS: Of the 234 subjects, 106 had alcohol as a major contributing factor (alcoholic liver disease: ALD), 80 of whom had evidence of cirrhosis or progressive fibrosis. Of these subjects, 57 (71%) drank on a daily basis; only 10 subjects (13%) drank on fewer than 4 days of the week--of these, five had stopped drinking recently and four had cut down. In ALD patients two life-time drinking patterns accounted for 82% of subjects, increasing from youth (51%), and a variable drinking pattern (31%). ALD patients had significantly more drinking days and units/drinking day than non-ALD patients from the age of 20 years onwards. CONCLUSIONS: Increases in UK liver deaths are a result of daily or near-daily heavy drinking, not episodic or binge drinking, and this regular drinking pattern is often discernable at an early age.
AIMS: To examine the hypothesis that increases in UK liver deaths are a result of episodic or binge drinking as opposed to regular harmful drinking. DESIGN: A prospective survey of consecutive in-patients and out-patients. SETTING: The liver unit of a teaching hospital in the South of England. PARTICIPANTS: A total of 234 consecutive in-patients and out-patients between October 2007 and March 2008. MEASUREMENTS: Face-to-face interviews, Alcohol Use Disorders Identification Test, 7-day drinking diary, Severity of Alcohol Dependence Questionnaire, Lifetime Drinking History and liver assessment. FINDINGS: Of the 234 subjects, 106 had alcohol as a major contributing factor (alcoholic liver disease: ALD), 80 of whom had evidence of cirrhosis or progressive fibrosis. Of these subjects, 57 (71%) drank on a daily basis; only 10 subjects (13%) drank on fewer than 4 days of the week--of these, five had stopped drinking recently and four had cut down. In ALDpatients two life-time drinking patterns accounted for 82% of subjects, increasing from youth (51%), and a variable drinking pattern (31%). ALDpatients had significantly more drinking days and units/drinking day than non-ALDpatients from the age of 20 years onwards. CONCLUSIONS: Increases in UK liver deaths are a result of daily or near-daily heavy drinking, not episodic or binge drinking, and this regular drinking pattern is often discernable at an early age.
Authors: Kelly P Cosgrove; Irina Esterlis; Graeme F Mason; Frederic Bois; Stephanie S O'Malley; John H Krystal Journal: Neuropharmacology Date: 2011-01-27 Impact factor: 5.250
Authors: Michael Roerecke; Afshin Vafaei; Omer S M Hasan; Bethany R Chrystoja; Marcus Cruz; Roy Lee; Manuela G Neuman; Jürgen Rehm Journal: Am J Gastroenterol Date: 2019-10 Impact factor: 10.864
Authors: David Zaridze; Paul Brennan; Jillian Boreham; Alex Boroda; Rostislav Karpov; Alexander Lazarev; Irina Konobeevskaya; Vladimir Igitov; Tatiana Terechova; Paolo Boffetta; Richard Peto Journal: Lancet Date: 2009-06-27 Impact factor: 79.321