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Literature DB >> 19214655

Melanoma cell differentiation induced by lupeol separates into two stages: morphological and functional changes.

Abstract

Electron microscopic observation revealed that lupeol induced melanosome maturation in B16 2F2 mouse melanoma cells and we therefore studied the effects of lupeol on the intracellular events responsible for melanosome transport. Incubation with lupeol for 8 h attenuated the actin stress fiber assembly in B16 2F2 mouse melanoma cells, resulting in dendritic formation in the cells. Longer exposure to lupeol (48 h) increased the expression of tyrosinase, MITF (a specific transcription factor for tyrosinase), Rab27a, and myosin-Va, which are required for melanosome transport.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19214655 DOI： 10.1007/s11418-009-0319-7

Source DB: PubMed Journal: J Nat Med ISSN： 1340-3443 Impact factor: 2.343

11 in total

1. Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes.

Authors: G Vancoillie; J Lambert; A Mulder; H K Koerten; A M Mommaas; P Van Oostveldt; J M Naeyaert
Journal: J Invest Dermatol Date: 2000-03 Impact factor: 8.551

2. Role of cytoplasmic dynein in melanosome transport in human melanocytes.

Authors: H R Byers; M Yaar; M S Eller; N L Jalbert; B A Gilchrest
Journal: J Invest Dermatol Date: 2000-05 Impact factor: 8.551

3. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation.

Authors: R Buscà; C Bertolotto; J P Ortonne; R Ballotti
Journal: J Biol Chem Date: 1996-12-13 Impact factor: 5.157

4. The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cells.

Authors: Glynis Scott; Sonya Leopardi
Journal: Pigment Cell Res Date: 2003-04

5. Remodeling of actin cytoskeleton in lupeol-induced B16 2F2 cell differentiation.

Authors: Keishi Hata; Kazuyuki Hori; Jun Murata; Saori Takahashi
Journal: J Biochem Date: 2005-10 Impact factor: 3.387

6. Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes.

Authors: Victoria M Virador; Jacqueline Muller; Xufneg Wu; Zalfa A Abdel-Malek; Zu-Xi Yu; Victor J Ferrans; Nobuhiko Kobayashi; Kazumasa Wakamatsu; Shosuke Ito; John A Hammer; Vincent J Hearing
Journal: FASEB J Date: 2001-11-29 Impact factor: 5.191

Review 7. Myosin-V, a versatile motor for short-range vesicle transport.

Authors: George M Langford
Journal: Traffic Date: 2002-12 Impact factor: 6.215

8. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.

Authors: Mitsunori Fukuda; Taruho S Kuroda; Katsuhiko Mikoshiba
Journal: J Biol Chem Date: 2002-02-20 Impact factor: 5.157

9. Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a and actin association.

Authors: Thierry Passeron; Philippe Bahadoran; Corine Bertolotto; Christine Chiaverini; Roser Buscà; Gaëlle Valony; Karine Bille; Jean-Paul Ortonne; Robert Ballotti
Journal: FASEB J Date: 2004-04-01 Impact factor: 5.191

Melanoma cell differentiation induced by lupeol separates into two stages: morphological and functional changes.

1. Kinesin and kinectin can associate with the melanosomal surface and form a link with microtubules in normal human melanocytes.

2. Role of cytoplasmic dynein in melanosome transport in human melanocytes.

3. Inhibition of the phosphatidylinositol 3-kinase/p70(S6)-kinase pathway induces B16 melanoma cell differentiation.

4. The cAMP signaling pathway has opposing effects on Rac and Rho in B16F10 cells: implications for dendrite formation in melanocytic cells.

5. Remodeling of actin cytoskeleton in lupeol-induced B16 2F2 cell differentiation.

6. Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes.

Review 7. Myosin-V, a versatile motor for short-range vesicle transport.

8. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.

9. Cyclic AMP promotes a peripheral distribution of melanosomes and stimulates melanophilin/Slac2-a and actin association.

10. Inhibition of Rho is required for cAMP-induced melanoma cell differentiation.

1. The dietary terpene lupeol targets colorectal cancer cells with constitutively active Wnt/β-catenin signaling.

Review 2. Botanicals for the prevention and treatment of cutaneous melanoma.

Review 3. Targeting drivers of melanoma with synthetic small molecules and phytochemicals.

4. Systemic and local injections of lupeol inhibit tumor growth in a melanoma-bearing mouse model.

Review 5. Possible Anticancer Mechanisms of Some Costus speciosus Active Ingredients Concerning Drug Discovery.