Literature DB >> 19214275

Applying organ clearance concepts in a clinical setting.

Jorge Duconge1.   

Abstract

OBJECTIVE: To teach doctor of pharmacy (PharmD) students how to apply organ clearance concepts in a clinical setting in order to optimize dose management, select the right drug product, and promote better patient-centered care practices.
DESIGN: A student-focused 5-hour topic entitled "Organ Clearance Concepts: Modeling and Clinical Applications" was developed and delivered to second-year PharmD students. Active-learning techniques, such as reading assignments and thought-provoking questions, and collaborative learning techniques, such as small groups, were used. Student learning was assessed using application cards and a minute paper. ASSESSMENT: Overall student responses to topic presentation were overwhelmingly positive. The teaching strategies here discussed allowed students to play an active role in their own learning process and provided the necessary connection to keep them motivated, as mentioned in the application cards and minute paper assessments. Students scored an average of 88% on the examination given at the end of the course.
CONCLUSION: By incorporating active-learning and collaborative-learning techniques in presenting material on organ clearance concept, students gained a more thorough knowledge of dose management and drug-drug interactions than if the concepts had been presented using a traditional lecture format. This knowledge will help students in solving critical patient situations in a real-world context.

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Year:  2008        PMID: 19214275      PMCID: PMC2630146          DOI: 10.5688/aj7205121

Source DB:  PubMed          Journal:  Am J Pharm Educ        ISSN: 0002-9459            Impact factor:   2.047


  18 in total

Review 1.  Changes in plasma protein binding have little clinical relevance.

Authors:  Leslie Z Benet; Betty-ann Hoener
Journal:  Clin Pharmacol Ther       Date:  2002-03       Impact factor: 6.875

2.  Commentary: a physiological approach to hepatic drug clearance.

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Journal:  Clin Pharmacol Ther       Date:  1975-10       Impact factor: 6.875

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4.  Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole.

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Journal:  Clin Pharmacol Ther       Date:  1977-11       Impact factor: 6.875

5.  Evaluation of route of input on the hepatic disposition of diazepam.

Authors:  S Sahin; M Rowland
Journal:  J Pharmacol Exp Ther       Date:  2000-11       Impact factor: 4.030

6.  Phenytoin cumulation kinetics.

Authors:  J P Allen; T M Ludden; S R Burrow; W A Clementi; S A Stavchansky
Journal:  Clin Pharmacol Ther       Date:  1979-10       Impact factor: 6.875

7.  Age and phenytoin kinetics in adult epileptics.

Authors:  L A Bauer; R A Blouin
Journal:  Clin Pharmacol Ther       Date:  1982-03       Impact factor: 6.875

8.  Phenytoin metabolism in pregnancy.

Authors:  N K Kochenour; M G Emery; R J Sawchuk
Journal:  Obstet Gynecol       Date:  1980-11       Impact factor: 7.661

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Authors:  G M Frigo; S Lecchini; G Gatti; E Perucca; A Crema
Journal:  Br J Clin Pharmacol       Date:  1979-12       Impact factor: 4.335

10.  Interaction between phenytoin and valproic acid: plasma protein binding and metabolic effects.

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Journal:  Clin Pharmacol Ther       Date:  1980-12       Impact factor: 6.875

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  2 in total

1.  A Database Developed with Information Extracted from Chemotherapy Drug Package Inserts to Enhance Future Prescriptions.

Authors:  Malcolm J D'Souza; Ghada J Alabed; Jordan M Wheatley; Natalia Roberts; Yogasudha Veturi; Xia Bi; Christopher Hart Continisio
Journal:  Conf Comput Vis Pattern Recognit Workshops       Date:  2011

2.  The understanding of core pharmacological concepts among health care students in their final semester.

Authors:  Patrik Aronsson; Shirley Booth; Staffan Hägg; Karin Kjellgren; Ann Zetterqvist; Gunnar Tobin; Margareta Reis
Journal:  BMC Med Educ       Date:  2015-12-29       Impact factor: 2.463

  2 in total

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