Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.

Literature DB >> 19212833

PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.

Donkena Krishna Vanaja¹, Michael E Grossmann, John C Cheville, Mozammel H Gazi, Aiyu Gong, Jin San Zhang, Katalin Ajtai, Thomas P Burghardt, Charles Y F Young.

Abstract

We investigated the molecular function of PDLIM4 in prostate cancer cells. PDLIM4 mRNA and protein-expression levels were reduced in LNCaP, LAPC4, DU145, CWR22, and PC3 prostate cancer cells. The re-expression of PDLIM4 in prostate cancer cells has significantly reduced the cell growth and clonogenicity with G1 phase of cell-cycle arrest. We have shown the direct interaction of PDLIM4 with F-actin. Restoration of PDLIM4 expression resulted in reduction of tumor growth in xenografts. These results suggest that PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2009 PMID： 19212833 PMCID： PMC3086358 DOI： 10.1080/07357900802406319

Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176

39 in total

1. The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.

Authors: E Cuppen; M van Ham; D G Wansink; A de Leeuw; B Wieringa; W Hendriks
Journal: Eur J Cell Biol Date: 2000-04 Impact factor: 4.492

2. FHL2, a novel tissue-specific coactivator of the androgen receptor.

Authors: J M Müller; U Isele; E Metzger; A Rempel; M Moser; A Pscherer; T Breyer; C Holubarsch; R Buettner; R Schüle
Journal: EMBO J Date: 2000-02-01 Impact factor: 11.598

3. The PDZ-LIM protein CLP36 is required for actin stress fiber formation and focal adhesion assembly in BeWo cells.

Authors: Naoaki Tamura; Koji Ohno; Taiichi Katayama; Naohiro Kanayama; Kohji Sato
Journal: Biochem Biophys Res Commun Date: 2007-10-22 Impact factor: 3.575

4. Gene expression of insulin-like growth factors and receptors in neoplastic prostate tissues: correlation with clinico-pathological parameters.

Authors: J A Figueroa; S De Raad; V O Speights; J J Rinehart
Journal: Cancer Invest Date: 2001 Impact factor: 2.176

5. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.

Authors: J B Welsh; L M Sapinoso; A I Su; S G Kern; J Wang-Rodriguez; C A Moskaluk; H F Frierson; G M Hampton
Journal: Cancer Res Date: 2001-08-15 Impact factor: 12.701

6. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein.

Authors: E S Tobias; A F Hurlstone; E MacKenzie; R McFarlane; D M Black
Journal: Oncogene Date: 2001-05-17 Impact factor: 9.867

7. Delineation of prognostic biomarkers in prostate cancer.

Authors: S M Dhanasekaran; T R Barrette; D Ghosh; R Shah; S Varambally; K Kurachi; K J Pienta; M A Rubin; A M Chinnaiyan
Journal: Nature Date: 2001-08-23 Impact factor: 49.962

8. Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton.

Authors: Yuhong Song; Raymond S Maul; C Sachi Gerbin; David D Chang
Journal: Mol Biol Cell Date: 2002-04 Impact factor: 4.138

9. PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers.

Authors: S Kang; H Xu; X Duan; J J Liu; Z He; F Yu; S Zhou; X Q Meng; M Cao; G C Kennedy
Journal: Cancer Res Date: 2000-09-15 Impact factor: 12.701

10. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.

Authors: Tea Vallenius; Tomi P Mäkelä
Journal: J Cell Sci Date: 2002-05-15 Impact factor: 5.285

18 in total

1. Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.

Authors: Hsiang-Yu Lin; Yi-Chiu Kuo; Yu-I Weng; I-Lu Lai; Tim H-M Huang; Shuan-Pei Lin; Dau-Ming Niu; Ching-Shih Chen
Journal: Prostate Date: 2012-04-26 Impact factor: 4.104

Review 2. Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.

Authors: Teodora Ribarska; Klaus-Marius Bastian; Annemarie Koch; Wolfgang A Schulz
Journal: Asian J Androl Date: 2012-02-27 Impact factor: 3.285

3. Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth.

Authors: Qiang Wu; Manish Kohli; H Robert Bergen; John C Cheville; R Jeffrey Karnes; Hong Cao; Charles Y F Young; Donald J Tindall; Mark A McNiven; Krishna Vanaja Donkena
Journal: Mol Cancer Ther Date: 2014-03-27 Impact factor: 6.261

PDLIM4, an actin binding protein, suppresses prostate cancer cell growth.

1. The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL.

2. FHL2, a novel tissue-specific coactivator of the androgen receptor.

3. The PDZ-LIM protein CLP36 is required for actin stress fiber formation and focal adhesion assembly in BeWo cells.

4. Gene expression of insulin-like growth factors and receptors in neoplastic prostate tissues: correlation with clinico-pathological parameters.

5. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer.

6. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein.

7. Delineation of prognostic biomarkers in prostate cancer.

8. Inhibition of anchorage-independent growth of transformed NIH3T3 cells by epithelial protein lost in neoplasm (EPLIN) requires localization of EPLIN to actin cytoskeleton.

9. PCD1, a novel gene containing PDZ and LIM domains, is overexpressed in several human cancers.

10. Clik1: a novel kinase targeted to actin stress fibers by the CLP-36 PDZ-LIM protein.

1. Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.

Review 2. Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation.

3. Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth.

4. Discovery of cellular substrates for protein kinase A using a peptide array screening protocol.

5. JMJD3 regulates CD4 T cell trafficking by targeting actin cytoskeleton regulatory gene Pdlim4.

6. Profiling of differentially expressed genes in cadmium-induced prostate carcinogenesis.

7. Novel diagnostic biomarkers for prostate cancer.

Review 8. Actin-Binding Proteins as Potential Biomarkers for Chronic Inflammation-Induced Cancer Diagnosis and Therapy.

9. Novel molecular targets of Azadirachta indica associated with inhibition of tumor growth in prostate cancer.

10. The histone demethylase Kdm3a is essential to progression through differentiation.