Literature DB >> 19212095

Expression of mRNA for 5-HT2 receptors and proteins related to inactivation of 5-HT in mouse osteoblasts.

Takao Hirai1, Kohji Tokumo, Daijyu Tsuchiya, Hiroaki Nishio.   

Abstract

We analyzed the expression of 5-HT(2) receptors and proteins related to inactivation of 5-HT in primary cultures of mouse osteoblasts. The mRNA for the 5-HT(2A) receptor was detectable in anaplastic osteoblasts as well as in differentiated and matured osteoblasts. The mRNA for the 5-HT(2B) receptor and 5-HT transporter was undetectable in anaplastic osteoblasts and became detectable in differentiated and matured osteoblasts. It was suggested that 5-HT might regulate the proliferation of anaplastic osteoblasts through the 5-HT(2A) receptor without control by 5-HT-inactivating mechanisms. The differentiation and maturation of osteoblasts might be regulated by the activation of the 5-HT(2B) receptor under the control of 5-HT inactivation.

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Year:  2009        PMID： 19212095     DOI： 10.1254/jphs.08243sc

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  5 in total

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Journal:  Bone       Date:  2009-07-08       Impact factor: 4.398

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Authors:  Stuart J Warden; Robyn K Fuchs
Journal:  Curr Osteoporos Rep       Date:  2016-10       Impact factor: 5.096

4.  The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.

Authors:  Shay Bracha; Austin Viall; Cheri Goodall; Bernadette Stang; Craig Ruaux; Bernard Seguin; Patrick E Chappell
Journal:  BMC Vet Res       Date:  2013-12-12       Impact factor: 2.741

5.  Serotonin regulates osteoblast proliferation and function in vitro.

Authors:  S Q Dai; L P Yu; X Shi; H Wu; P Shao; G Y Yin; Y Z Wei
Journal:  Braz J Med Biol Res       Date:  2014-08-01       Impact factor: 2.590
  5 in total

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