Literature DB >> 19211967

GABA(B) receptors in drug addiction.

Małgorzata Filip1, Małgorzata Frankowska.   

Abstract

Preclinical studies and clinical trials carried out within the past few years have provided a premise that gamma-aminobutyric acid (GABA) transmission and GABA(B) receptors play a modulatory role in the mechanism of action of different drugs of abuse. The present review summarizes the contribution of GABA(B) receptors to the rewarding, locomotor and discriminative stimulus properties of drugs of abuse and their withdrawal symptoms in laboratory animals. It also reviews the current knowledge about the GABA(B) receptor ligands in clinical trials, with a focus on their effects on presentation of the drug-associated cues and withdrawal-induced drug craving.

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Year:  2008        PMID： 19211967

Source DB:  PubMed          Journal:  Pharmacol Rep        ISSN： 1734-1140            Impact factor:   3.024


  15 in total

1.  Chronic baclofen desensitizes GABA(B)-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain.

Authors:  Bradley M T Keegan; Thomas J R Beveridge; Jeffrey J Pezor; Ruoyu Xiao; Tammy Sexton; Steven R Childers; Allyn C Howlett
Journal:  Neuropharmacology       Date:  2015-02-25       Impact factor: 5.250

2.  Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1.

Authors:  Guillaume Bony; Joanna Szczurkowska; Ilaria Tamagno; Maya Shelly; Andrea Contestabile; Laura Cancedda
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

Review 3.  GABAB receptor complex as a potential target for tumor therapy.

Authors:  Xinnong Jiang; Li Su; Qian Zhang; Cong He; Zhongling Zhang; Ping Yi; Jianfeng Liu
Journal:  J Histochem Cytochem       Date:  2012-01-20       Impact factor: 2.479

Review 4.  Functional modulation of GABAB receptors by protein kinases and receptor trafficking.

Authors:  Miho Terunuma; Menelas N Pangalos; Stephen J Moss
Journal:  Adv Pharmacol       Date:  2010

5.  Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation.

Authors:  Julie Vienne; Bernhard Bettler; Paul Franken; Mehdi Tafti
Journal:  J Neurosci       Date:  2010-10-20       Impact factor: 6.167

Review 6.  Pharmacotherapeutic approach to the treatment of addiction: persistent challenges.

Authors:  Daniel S Zahm
Journal:  Mo Med       Date:  2010 Jul-Aug

7.  GABAB agonism promotes sleep and reduces cataplexy in murine narcolepsy.

Authors:  Sarah Wurts Black; Stephen R Morairty; Tsui-Ming Chen; Andrew K Leung; Jonathan P Wisor; Akihiro Yamanaka; Thomas S Kilduff
Journal:  J Neurosci       Date:  2014-05-07       Impact factor: 6.167

8.  Viral Vector-Mediated Gene Transfer of Glutamic Acid Decarboxylase for Chronic Pain Treatment: A Literature Review.

Authors:  Megumi Kanao-Kanda; Hirotsugu Kanda; Shue Liu; Sabita Roy; Michal Toborek; Shuanglin Hao
Journal:  Hum Gene Ther       Date:  2020-03-24       Impact factor: 5.695

9.  Involvement of reactive oxygen species in cocaine-taking behaviors in rats.

Authors:  Eun Young Jang; Yeon-Hee Ryu; Bong Hyo Lee; Su-Chan Chang; Mi Jin Yeo; Sang Hyun Kim; Ryan J Folsom; Nathan D Schilaty; Kwang Joong Kim; Chae Ha Yang; Scott C Steffensen; Hee Young Kim
Journal:  Addict Biol       Date:  2014-06-26       Impact factor: 4.280

10.  Male-specific association of the 2p25 region with suicide attempt in bipolar disorder.

Authors:  Sophia C Gaynor; Eric T Monson; Marie E Gaine; Michael S Chimenti; Rachel D Reichman; Meredith Parsons; Lalita Oonthonpan; Peter P Zandi; James B Potash; Virginia L Willour
Journal:  J Psychiatr Res       Date:  2019-11-18       Impact factor: 4.791
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