BACKGROUND: Iron absorption is proposed to be regulated by circulating hepcidin, but, to date, little data are available to evaluate this relation in humans. OBJECTIVE: Stored samples from a human iron absorption study were used to test the hypothesis that differences in plasma hepcidin explain interindividual variation in iron absorption. DESIGN: Hepcidin-25 concentrations were measured in fasting samples from men aged > or = 40 y (n = 33) recruited to a study investigating the relation between the HFE genotype, iron absorption, and iron status. RESULTS: Log iron absorption was negatively correlated with serum ferritin (r = -0.59, P < 0.001) and with plasma hepcidin (r = -0.55, P < 0.001) but was unaffected by genotype. There was a positive correlation (r = 0.82, P < 0.001) between hepcidin (mean: 2.3; range: 0.1-7.8 nmol/L) and ferritin (mean: 70; range: 9-208 microg/L). Multiple linear regression models showed that plasma hepcidin in isolation significantly predicted 36% of the interindividual variation in iron absorption. CONCLUSIONS: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.
BACKGROUND:Iron absorption is proposed to be regulated by circulating hepcidin, but, to date, little data are available to evaluate this relation in humans. OBJECTIVE: Stored samples from a humaniron absorption study were used to test the hypothesis that differences in plasma hepcidin explain interindividual variation in iron absorption. DESIGN:Hepcidin-25 concentrations were measured in fasting samples from men aged > or = 40 y (n = 33) recruited to a study investigating the relation between the HFE genotype, iron absorption, and iron status. RESULTS: Log iron absorption was negatively correlated with serum ferritin (r = -0.59, P < 0.001) and with plasma hepcidin (r = -0.55, P < 0.001) but was unaffected by genotype. There was a positive correlation (r = 0.82, P < 0.001) between hepcidin (mean: 2.3; range: 0.1-7.8 nmol/L) and ferritin (mean: 70; range: 9-208 microg/L). Multiple linear regression models showed that plasma hepcidin in isolation significantly predicted 36% of the interindividual variation in iron absorption. CONCLUSIONS: Plasma hepcidin and serum ferritin concentrations are highly correlated, and, in the normal range of plasma hepcidin values, 36% of interindividual differences in iron absorption are explained by differences in circulating plasma hepcidin.
Authors: Melissa F Young; Ian Griffin; Eva Pressman; Allison W McIntyre; Elizabeth Cooper; Thomas McNanley; Z Leah Harris; Mark Westerman; Kimberly O O'Brien Journal: J Nutr Date: 2011-11-23 Impact factor: 4.798
Authors: Melissa F Young; Ian Griffin; Eva Pressman; Allison W McIntyre; Elizabeth Cooper; Thomas McNanley; Z Leah Harris; Mark Westerman; Kimberly O O'Brien Journal: J Nutr Date: 2010-10-27 Impact factor: 4.798
Authors: Alan E Mast; Aniko Szabo; Mars Stone; Ritchard G Cable; Bryan R Spencer; Joseph E Kiss Journal: Am J Hematol Date: 2020-04-15 Impact factor: 10.047