Literature DB >> 19211052

Hedgehog signaling: is Smo a G protein-coupled receptor?

Melanie Philipp1, Marc G Caron.   

Abstract

The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.

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Year:  2009        PMID： 19211052     DOI： 10.1016/j.cub.2008.12.010

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  21 in total

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Authors:  Tama Evron; Tanya L Daigle; Marc G Caron
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Review 2.  The G protein Gαs acts as a tumor suppressor in sonic hedgehog signaling-driven tumorigenesis.

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Journal:  Cell Cycle       Date:  2016-05-18       Impact factor: 4.534

Review 3.  Neurotransmitter signaling in postnatal neurogenesis: The first leg.

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Review 4.  Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms.

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Journal:  Am J Pathol       Date:  2011-11-01       Impact factor: 4.307

5.  Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics.

Authors:  Bryn S Moore; Ann N Stepanchick; Paul H Tewson; Cassandra M Hartle; Jin Zhang; Anne Marie Quinn; Thomas E Hughes; Tooraj Mirshahi
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-31       Impact factor: 11.205

6.  Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

Authors:  Nicholas W Plummer; Karsten Spicher; Jason Malphurs; Haruhiko Akiyama; Joel Abramowitz; Bernd Nürnberg; Lutz Birnbaumer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-11       Impact factor: 11.205

Review 7.  Minireview: steroidogenic factor 1: its roles in differentiation, development, and disease.

Authors:  Bernard P Schimmer; Perrin C White
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8.  Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.

Authors:  Tomoya Kotani; Shun-ichiro Iemura; Tohru Natsume; Koichi Kawakami; Masakane Yamashita
Journal:  J Biol Chem       Date:  2009-12-14       Impact factor: 5.157

Review 9.  Proximal events in Wnt signal transduction.

Authors:  Stephane Angers; Randall T Moon
Journal:  Nat Rev Mol Cell Biol       Date:  2009-07       Impact factor: 94.444

Review 10.  Signaling mechanisms regulating adult neural stem cells and neurogenesis.

Authors:  Roland Faigle; Hongjun Song
Journal:  Biochim Biophys Acta       Date:  2012-09-12
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