Literature DB >> 19210260

Temporal changes in characteristics of injection-site sarcomas in cats: 392 cases (1990-2006).

Stephen C Shaw1, Michael S Kent, Ira K Gordon, Cameron J Collins, Tamara A Greasby, Laurel A Beckett, Genevieve M Hammond, Katherine A Skorupski.   

Abstract

OBJECTIVE: To evaluate changes in characteristics of feline injection-site sarcomas (ISSs) from 1990 through 2006.
DESIGN: Retrospective case series. ANIMALS: 392 cats with a histologic diagnosis of soft tissue sarcoma, osteosarcoma, or chondrosarcoma at potential injection sites. PROCEDURES: Classification and anatomic location of tumors and signalment of affected cats were compared between ISSs diagnosed before and after publication of the Vaccine Associated Feline Sarcoma Task Force vaccination recommendations in 1996.
RESULTS: From before to after publication of the vaccination recommendations, proportions of ISSs significantly decreased in the interscapular (53.4% to 39.5%) and right and left thoracic (10.2% to 3.6% and 9.1% to 1.3%, respectively) regions. On the other hand, proportions of ISSs significantly increased in the right thoracic limb (1.1% to 9.5%) and the combined regions of the right pelvic limb with right lateral aspect of the abdomen (12.5% to 25.0%) and the left pelvic limb with left lateral aspect of the abdomen (11.4% to 13.8%). Patterns of tumor classification and signalment did not change. CONCLUSIONS AND CLINICAL RELEVANCE: Despite publication of the vaccination recommendations, a high proportion of tumors still developed in the interscapular region. There was also an increase in lateral abdominal ISSs, which are more difficult to treat and are likely attributable to aberrant placement of injections intended for the pelvic limbs. Veterinarians are complying with vaccination recommendations to some extent, but they need to focus on administering vaccines as distally as possible on a limb to allow for complete surgical margins if amputation of a limb is required.

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Year:  2009        PMID: 19210260      PMCID: PMC5404116          DOI: 10.2460/javma.234.3.376

Source DB:  PubMed          Journal:  J Am Vet Med Assoc        ISSN: 0003-1488            Impact factor:   1.936


  19 in total

1.  Vaccine-associated-like fibrosarcoma at the site of a deep nonabsorbable suture in a cat.

Authors:  P Buracco; M Martano; E Morello; A Ratto
Journal:  Vet J       Date:  2002-01       Impact factor: 2.688

2.  Prognosis for presumed feline vaccine-associated sarcoma after excision: 61 cases (1986-1996).

Authors:  A E Hershey; K U Sorenmo; M J Hendrick; F S Shofer; D M Vail
Journal:  J Am Vet Med Assoc       Date:  2000-01-01       Impact factor: 1.936

3.  Feline fibrosarcomas at vaccination sites and non-vaccination sites.

Authors:  F D Doddy; L T Glickman; N W Glickman; E B Janovitz
Journal:  J Comp Pathol       Date:  1996-02       Impact factor: 1.311

4.  Postvaccinal sarcomas in the cat: histology and immunohistochemistry.

Authors:  M J Hendrick; J J Brooks
Journal:  Vet Pathol       Date:  1994-01       Impact factor: 2.221

5.  Surgical excision of soft tissue fibrosarcomas in cats.

Authors:  E B Davidson; C R Gregory; P H Kass
Journal:  Vet Surg       Date:  1997 Jul-Aug       Impact factor: 1.495

6.  Do postvaccinal sarcomas occur in Australian cats?

Authors:  G Burton; K V Mason
Journal:  Aust Vet J       Date:  1997-02       Impact factor: 1.281

7.  Preoperative radiotherapy for vaccine associated sarcoma in 92 cats.

Authors:  Tetsuya Kobayashi; Marlene L Hauck; Richard Dodge; Rodney L Page; G Sylvester Price; Laurel E Williams; Elizabeth M Hardie; Kyle G Mathews; Donald E Thrall
Journal:  Vet Radiol Ultrasound       Date:  2002 Sep-Oct       Impact factor: 1.363

8.  Radiation therapy and surgery for fibrosarcoma in 33 cats.

Authors:  K Cronin; R L Page; G Spodnick; R Dodge; E N Hardie; G S Price; D Ruslander; D E Thrall
Journal:  Vet Radiol Ultrasound       Date:  1998 Jan-Feb       Impact factor: 1.363

9.  Epidemiologic evidence for a causal relation between vaccination and fibrosarcoma tumorigenesis in cats.

Authors:  P H Kass; W G Barnes; W L Spangler; B B Chomel; M R Culbertson
Journal:  J Am Vet Med Assoc       Date:  1993-08-01       Impact factor: 1.936

10.  Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats.

Authors:  Philip H Kass; William L Spangler; Mattie J Hendrick; Lawrence D McGill; D Glen Esplin; Sally Lester; Margaret Slater; E Kathryn Meyer; Faith Boucher; Erika M Peters; Glenna G Gobar; Thurein Htoo; Kendra Decile
Journal:  J Am Vet Med Assoc       Date:  2003-11-01       Impact factor: 1.936

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  6 in total

1.  WSAVA guidelines for the vaccination of dogs and cats.

Authors:  M J Day; M C Horzinek; R D Schultz
Journal:  J Small Anim Pract       Date:  2010-06       Impact factor: 1.522

2.  Feline postvaccinal sarcoma: 20 years later.

Authors:  Brian Wilcock; Anne Wilcock; Katherine Bottoms
Journal:  Can Vet J       Date:  2012-04       Impact factor: 1.008

3.  WSAVA Guidelines for the vaccination of dogs and cats.

Authors:  M J Day; M C Horzinek; R D Schultz; R A Squires
Journal:  J Small Anim Pract       Date:  2016-01       Impact factor: 1.522

4.  Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection-site sarcoma.

Authors:  Mary J Coleman; Laura E Selmic; Jonathan P Samuelson; Ryan Jennings; Pin-Chieh Huang; Eric M McLaughlin; Vincent A Wavreille; Josephine A Dornbusch; Janis Lapsley; James Howard; Edward Cheng; Alex Kalamaras; Kendra Hearon; Megan Cray; Janet Grimes; Brandan Wustefeld-Janssens; Katie Kennedy; Owen Skinner; Pierre Amsellem; Stephen A Boppart
Journal:  Vet Comp Oncol       Date:  2021-09-14       Impact factor: 2.613

Review 5.  Vaccine-associated feline sarcoma: current perspectives.

Authors:  Corey F Saba
Journal:  Vet Med (Auckl)       Date:  2017-01-12

6.  Origins of injection-site sarcomas in cats: the possible role of chronic inflammation-a review.

Authors:  Kevin N Woodward
Journal:  ISRN Vet Sci       Date:  2011-04-12
  6 in total

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