Literature DB >> 19208673

Ethical issues of clinical trials in children: a European perspective.

H Sammons1.   

Abstract

Children should not be harmed by their participation in clinical trials, therefore should no clinical trials be performed? This is a view that needs to be balanced as clinical trials provide the evidence we need to allow children safe and effective prescribing of medicines. Therefore, is it unethical not to involve this population in research? This review looks at new ethical guidance released to support the recently introduced European legislation for the licensing of medicines.

Entities:  

Mesh：

Year:  2009        PMID： 19208673     DOI： 10.1136/adc.2008.149898

Source DB:  PubMed          Journal:  Arch Dis Child        ISSN： 0003-9888            Impact factor:   3.791


  18 in total

1.  Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury.

Authors:  David J Askenazi; Catherine Morgan; Stuart L Goldstein; David T Selewski; Marva M Moxey-Mims; Paul L Kimmel; Robert A Star; Rosemary Higgins; Matthew Laughon
Journal:  Pediatr Res       Date:  2015-11-23       Impact factor: 3.756

Review 2.  Innovative clinical trial design for pediatric therapeutics.

Authors:  Matthew M Laughon; Daniel K Benjamin; Edmund V Capparelli; Gregory L Kearns; Katherine Berezny; Ian M Paul; Kelly Wade; Jeff Barrett; Phillip Brian Smith; Michael Cohen-Wolkowiez
Journal:  Expert Rev Clin Pharmacol       Date:  2011-09       Impact factor: 5.045

Review 3.  Framework conditions facilitating paediatric clinical research.

Authors:  Anne-Laure Knellwolf; Stéphane Bauzon; Ornella Della Casa Alberighi; Irja Lutsar; Ernö Bácsy; Deborah Alfarez; Pietro Panei
Journal:  Ital J Pediatr       Date:  2011-02-23       Impact factor: 2.638

Review 4.  Clinical research in newborn infants: difficulties and specificity.

Authors:  Isabelle Ligi; Farid Boubred; Isabelle Grandvuillemin; Umberto Simeoni
Journal:  Eur J Clin Pharmacol       Date:  2010-11-18       Impact factor: 2.953

5.  Children's views on unlicensed/off-label paediatric prescribing and paediatric clinical trials.

Authors:  Tareq Mukattash; Karen Trew; Ahmed F Hawwa; James C McElnay
Journal:  Eur J Clin Pharmacol       Date:  2011-08-17       Impact factor: 2.953

6.  In Vitro Determination of Respimat® Dose Delivery in Children: An Evaluation Based on Inhalation Flow Profiles and Mouth-Throat Models.

Authors:  Deborah Bickmann; Wolfgang Kamin; Ashish Sharma; Herbert Wachtel; Petra Moroni-Zentgraf; Stefan Zielen
Journal:  J Aerosol Med Pulm Drug Deliv       Date:  2015-06-22       Impact factor: 2.849

7.  Healthcare professional experiences and attitudes on unlicensed/off-label paediatric prescribing and paediatric clinical trials.

Authors:  Tareq Mukattash; Ahmed F Hawwa; Karen Trew; James C McElnay
Journal:  Eur J Clin Pharmacol       Date:  2011-01-18       Impact factor: 2.953

Review 8.  Therapeutic misconception: hope, trust and misconception in paediatric research.

Authors:  Simon Woods; Lynn E Hagger; Pauline McCormack
Journal:  Health Care Anal       Date:  2014-03

Review 9.  Clinical trials in children.

Authors:  Pathma D Joseph; Jonathan C Craig; Patrina H Y Caldwell
Journal:  Br J Clin Pharmacol       Date:  2015-03       Impact factor: 4.335

Review 10.  Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood.

Authors:  Robert S Phillips; Amanda J Friend; Faith Gibson; Elizabeth Houghton; Shireen Gopaul; Jean V Craig; Barry Pizer
Journal:  Cochrane Database Syst Rev       Date:  2016-02-02
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