AIM: The DD genotype of angiotensin-converting enzyme (ACE) has been suggested as a major contributor of diabetic nephropathy in several populations. The purpose of the present study was to determine whether micro/macroalbuminuria is associated with ACE insertion/deletion (I/D) polymorphism in Mexican Mestizos with type 2 diabetes mellitus. METHODS: A total of 435 patients with type 2 diabetes mellitus, of whom 233 had albuminuria, were characterized for the ACE I/D polymorphism by the polymerase chain reaction method. RESULTS: Clinical and biochemical characteristics and frequencies according to DD, ID and II genotypes in patients with and without albuminuria showed no significant differences. However, only females with micro/macroalbuminuria showed higher frequency of a DD genotype than those without albuminuria (27.9%, 21.2% and 10.5%, respectively; P <or= 0.044). In addition, female patients with macroalbuminuria without dialysis showed no significant differences with patients undergoing dialysis. CONCLUSION: The ACE DD genotype is a risk factor for the development of renal disease in Mexican Mestizo females with type 2 diabetes, indicating a possible DD genotype-associated sex effect in renal disease.
AIM: The DD genotype of angiotensin-converting enzyme (ACE) has been suggested as a major contributor of diabetic nephropathy in several populations. The purpose of the present study was to determine whether micro/macroalbuminuria is associated with ACE insertion/deletion (I/D) polymorphism in Mexican Mestizos with type 2 diabetes mellitus. METHODS: A total of 435 patients with type 2 diabetes mellitus, of whom 233 had albuminuria, were characterized for the ACE I/D polymorphism by the polymerase chain reaction method. RESULTS: Clinical and biochemical characteristics and frequencies according to DD, ID and II genotypes in patients with and without albuminuria showed no significant differences. However, only females with micro/macroalbuminuria showed higher frequency of a DD genotype than those without albuminuria (27.9%, 21.2% and 10.5%, respectively; P <or= 0.044). In addition, female patients with macroalbuminuria without dialysis showed no significant differences with patients undergoing dialysis. CONCLUSION: The ACE DD genotype is a risk factor for the development of renal disease in Mexican Mestizo females with type 2 diabetes, indicating a possible DD genotype-associated sex effect in renal disease.
Authors: Laura E Martínez-Gómez; Brígida Herrera-López; Carlos Martinez-Armenta; Silvestre Ortega-Peña; María Del Carmen Camacho-Rea; Carlos Suarez-Ahedo; Paola Vázquez-Cárdenas; Gilberto Vargas-Alarcón; Gustavo Rojas-Velasco; José Manuel Fragoso; Patricia Vidal-Vázquez; Juan P Ramírez-Hinojosa; Yunuen Rodríguez-Sánchez; David Barrón-Díaz; Mariana L Moreno; Felipe de J Martínez-Ruiz; Dulce M Zayago-Angeles; Mónica Maribel Mata-Miranda; Gustavo Jesús Vázquez-Zapién; Adriana Martínez-Cuazitl; Edith Barajas-Galicia; Ludwing Bustamante-Silva; Diana Zazueta-Arroyo; José Manuel Rodríguez-Pérez; Olivia Hernández-González; Roberto Coronado-Zarco; Vania Lucas-Tenorio; Rafael Franco-Cendejas; Luis Esau López-Jácome; Rocío Carmen Vázquez-Juárez; Jonathan J Magaña; Marlid Cruz-Ramos; Julio Granados; Susana Hernández-Doño; Diego Delgado-Saldivar; Luis Ramos-Tavera; Irma Coronado-Zarco; Gustavo Guajardo-Salinas; José Francisco Muñoz-Valle; Carlos Pineda; Gabriela Angélica Martínez-Nava; Alberto López-Reyes Journal: Front Immunol Date: 2022-02-17 Impact factor: 7.561