S K Cakmak1, U Gül, C Kiliç, M Gönül, S Soylu, A Kiliç. 1. 2nd Dermatology Clinic, Ankara Numune Education and Research Hospital, Ministry of Health, Ankara, Turkey. seraycakmak@gmail.com
Abstract
BACKGROUND: Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported. AIM: The aim of our study was to examine serum homocysteine, folic acid and vitamin B12 levels in psoriasis patients. MATERIAL AND METHODS: We performed a cross-sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age- and gender-matched controls. Serum levels of homocysteine, vitamin B12 and folic acid levels were measured in both groups. RESULTS: Serum homocysteine, folic acid and vitamin B12 levels did not differ between patient and control groups. In psoriasis patients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group. DISCUSSION: Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.
BACKGROUND: Hyperhomocysteinaemia is a risk factor for atherosclerotic cardiovascular disease, stroke, peripheral arterial occlusive disease and venous thrombosis. An association between psoriasis and cardiovascular diseases has been reported. AIM: The aim of our study was to examine serum homocysteine, folic acid and vitamin B12 levels in psoriasispatients. MATERIAL AND METHODS: We performed a cross-sectional study in 70 consecutive outpatients with chronic plaque psoriasis and 70 age- and gender-matched controls. Serum levels of homocysteine, vitamin B12 and folic acid levels were measured in both groups. RESULTS: Serum homocysteine, folic acid and vitamin B12 levels did not differ between patient and control groups. In psoriasispatients, homocysteine levels correlated directly with psoriasis severity as measured by psoriasis area and severity index. Serum homocysteine level inversely correlated with serum folic acid levels in the patient group. DISCUSSION: Homocysteine levels correlated with psoriasis area and severity index in the patient group, which shows the disease severity. The increase in cardiovascular mortality with the severity of psoriasis might be also due to the effects of homocysteine.
Authors: Rita V Patel; Michael L Shelling; Srdjan Prodanovich; Daniel G Federman; Robert S Kirsner Journal: J Gen Intern Med Date: 2011-04-07 Impact factor: 5.128
Authors: Jung Eun Kim; Ho Jung Lee; Jong Suk Lee; Kyu Uang Whang; Young Lip Park; Sung Yul Lee; Hyun Jung Kim Journal: Ann Dermatol Date: 2019-07-01 Impact factor: 1.444