Literature DB >> 19206385

Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles.

Partha S Ghosh1, Chae-Kyu Kim, Gang Han, Neil S Forbes, Vincent M Rotello.   

Abstract

Gold colloids functionalized with amino acids provide a scaffold for effective DNA binding with subsequent condensation. Particles with lysine and lysine dendron functionality formed particularly compact complexes and provided highly efficient gene delivery without any observed cytotoxicity. Nanoparticles functionalized with first generation lysine dendrons (NP-LysG1) were approximately 28-fold superior to polylysine in reporter gene expression. These amino acid-based nanoparticles were responsive to intracellular glutathione levels, providing a tool for controlled release and concomitant expression of DNA.

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Year:  2008        PMID： 19206385      PMCID： PMC2643365          DOI： 10.1021/nn800507t

Source DB:  PubMed          Journal:  ACS Nano        ISSN： 1936-0851            Impact factor:   15.881


  44 in total

1.  Gold nanoparticle-mediated transfection of mammalian cells.

Authors:  Kulmeet K Sandhu; Catherine M McIntosh; Joseph M Simard; Sallie W Smith; Vincent M Rotello
Journal:  Bioconjug Chem       Date:  2002 Jan-Feb       Impact factor: 4.774

2.  Polylysine-based transfection systems utilizing receptor-mediated delivery.

Authors: 
Journal:  Adv Drug Deliv Rev       Date:  1998-03-02       Impact factor: 15.470

3.  Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer.

Authors:  Nobuhiro Nishiyama; Aya Iriyama; Woo-Dong Jang; Kanjiro Miyata; Keiji Itaka; Yuji Inoue; Hidenori Takahashi; Yasuo Yanagi; Yasuhiro Tamaki; Hiroyuki Koyama; Kazunori Kataoka
Journal:  Nat Mater       Date:  2005-11-20       Impact factor: 43.841

4.  Gene therapy put on hold as third child develops cancer.

Authors:  Erika Check
Journal:  Nature       Date:  2005-02-10       Impact factor: 49.962

5.  Examination of the biophysical interaction between plasmid DNA and the polycations, polylysine and polyornithine, as a basis for their differential gene transfection in-vitro.

Authors:  E Ramsay; J Hadgraft; J Birchall; M Gumbleton
Journal:  Int J Pharm       Date:  2000-12-04       Impact factor: 5.875

6.  Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione.

Authors:  Gang Han; Nandini S Chari; Ayush Verma; Rui Hong; Craig T Martin; Vincent M Rotello
Journal:  Bioconjug Chem       Date:  2005 Nov-Dec       Impact factor: 4.774

7.  Hydroxyl stereochemistry and amine number within poly(glycoamidoamine)s affect intracellular DNA delivery.

Authors:  Yemin Liu; Theresa M Reineke
Journal:  J Am Chem Soc       Date:  2005-03-09       Impact factor: 15.419

Review 8.  Water insoluble and soluble lipids for gene delivery.

Authors:  Ram I Mahato
Journal:  Adv Drug Deliv Rev       Date:  2005-04-05       Impact factor: 15.470

9.  Residue-specific pKa determination of lysine and arginine side chains by indirect 15N and 13C NMR spectroscopy: application to apo calmodulin.

Authors:  Ingemar André; Sara Linse; Frans A A Mulder
Journal:  J Am Chem Soc       Date:  2007-11-29       Impact factor: 15.419

10.  Dendrimer-entrapped gold nanoparticles as a platform for cancer-cell targeting and imaging.

Authors:  Xiangyang Shi; Suhe Wang; Sasha Meshinchi; Mary E Van Antwerp; Xiangdong Bi; Inhan Lee; James R Baker
Journal:  Small       Date:  2007-07       Impact factor: 13.281
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  88 in total

Review 1.  Gold nanoparticles: preparation, properties, and applications in bionanotechnology.

Authors:  Yi-Cheun Yeh; Brian Creran; Vincent M Rotello
Journal:  Nanoscale       Date:  2011-11-10       Impact factor: 7.790

Review 2.  Gene therapy in the cornea: 2005--present.

Authors:  Rajiv R Mohan; Jonathan C K Tovey; Ajay Sharma; Ashish Tandon
Journal:  Prog Retin Eye Res       Date:  2011-09-28       Impact factor: 21.198

3.  pH-Sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells.

Authors:  Hyejung Mok; Omid Veiseh; Chen Fang; Forrest M Kievit; Freddy Y Wang; James O Park; Miqin Zhang
Journal:  Mol Pharm       Date:  2010-09-14       Impact factor: 4.939

4.  Monitoring the Photocleaving Dynamics of Colloidal MicroRNA-Functionalized Gold Nanoparticles Using Second Harmonic Generation.

Authors:  Raju R Kumal; Corey R Landry; Mohammad Abu-Laban; Daniel J Hayes; Louis H Haber
Journal:  Langmuir       Date:  2015-09-03       Impact factor: 3.882

5.  Gene delivery through the use of a hyaluronate-associated intracellularly degradable crosslinked polyethyleneimine.

Authors:  Peisheng Xu; Griffin K Quick; Yoon Yeo
Journal:  Biomaterials       Date:  2009-07-25       Impact factor: 12.479

6.  The effects of size, shape, and surface functional group of gold nanostructures on their adsorption and internalization by cells.

Authors:  Eun Chul Cho; Leslie Au; Qiang Zhang; Younan Xia
Journal:  Small       Date:  2010-02-22       Impact factor: 13.281

Review 7.  Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia.

Authors:  Chengyi Tu; Subhamoy Das; Aaron B Baker; Janeta Zoldan; Laura J Suggs
Journal:  ACS Nano       Date:  2015-04-10       Impact factor: 15.881

8.  Optimization of PAMAM-gold nanoparticle conjugation for gene therapy.

Authors:  Elizabeth R Figueroa; Adam Y Lin; Jiaxi Yan; Laureen Luo; Aaron E Foster; Rebekah A Drezek
Journal:  Biomaterials       Date:  2013-11-26       Impact factor: 12.479

9.  Histone-Mimetic Gold Nanoparticles as Versatile Scaffolds for Gene Transfer and Chromatin Analysis.

Authors:  Erik V Munsell; Bing Fang; Millicent O Sullivan
Journal:  Bioconjug Chem       Date:  2018-10-29       Impact factor: 4.774

10.  Recognition-mediated activation of therapeutic gold nanoparticles inside living cells.

Authors:  Chaekyu Kim; Sarit S Agasti; Zhengjiang Zhu; Lyle Isaacs; Vincent M Rotello
Journal:  Nat Chem       Date:  2010-10-03       Impact factor: 24.427
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