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Literature DB >> 19205915

A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.

Issa Yavari¹, Zinatossadat Hossaini, Maryam Sabbaghan, Majid Ghazanfarpour-Darjani.

Abstract

An efficient one-pot synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates using acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate is described.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19205915 DOI： 10.1007/s11030-009-9114-3

Source DB: PubMed Journal: Mol Divers ISSN： 1381-1991 Impact factor: 2.943

13 in total

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Authors: Christina Papadopoulou; Athina Geronikaki; Dimitra Hadjipavlou-Litina
Journal: Farmaco Date: 2005-07-22

2. WS75624 A and B, new endothelin converting enzyme inhibitors isolated from Saccharothrix sp. No. 75624. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.

Authors: Y Tsurumi; H Ueda; K Hayashi; S Takase; M Nishikawa; S Kiyoto; M Okuhara
Journal: J Antibiot (Tokyo) Date: 1995-10 Impact factor: 2.649

3. Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.

Authors: Seiji Miwatashi; Yasuyoshi Arikawa; Etsuo Kotani; Maki Miyamoto; Ken-Ichi Naruo; Hiroyuki Kimura; Toshimasa Tanaka; Satoru Asahi; Shigenori Ohkawa
Journal: J Med Chem Date: 2005-09-22 Impact factor: 7.446

4. Synthesis of 2,4-disubstituted thiazoles from (Z)-(2-acetoxyvinyl)phenyl-lambda3-iodanes: nucleophilic substitution of alpha-lambda3-iodanyl ketones with thioureas and thioamides.

Authors: Masahito Ochiai; Yoshio Nishi; Sakiko Hashimoto; Yoshimi Tsuchimoto; Da-Wei Chen
Journal: J Org Chem Date: 2003-10-03 Impact factor: 4.354

5. Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors.

Authors: Sampath-Kumar Anandan; John S Ward; Richard D Brokx; Trisha Denny; Mark R Bray; Dinesh V Patel; Xiao-Yi Xiao
Journal: Bioorg Med Chem Lett Date: 2007-08-19 Impact factor: 2.823

6. Phenethylthiazolethiourea (PETT) compounds, a new class of HIV-1 reverse transcriptase inhibitors. 1. Synthesis and basic structure-activity relationship studies of PETT analogs.

Authors: F W Bell; A S Cantrell; M Högberg; S R Jaskunas; N G Johansson; C L Jordan; M D Kinnick; P Lind; J M Morin; R Noréen
Journal: J Med Chem Date: 1995-12-08 Impact factor: 7.446

7. Synthesis of 2,4-disubstituted thiazoles and selenazoles as potential antitumor and antifilarial agents: 1. Methyl 4-(isothiocyanatomethyl)thiazole-2-carbamates, -selenazole-2- carbamates, and related derivatives.

Authors: Y Kumar; R Green; K Z Borysko; D S Wise; L L Wotring; L B Townsend
Journal: J Med Chem Date: 1993-11-26 Impact factor: 7.446

1. Facile and efficient synthesis of functionalized iminothiopyran and isothiochromen via one-pot multicomponent reactions.

Authors: Hosein Hamadi; Mehdi Khoobi; Zinatossadat Hossaini; Abbas Shafiee
Journal: Mol Divers Date: 2010-04-22 Impact factor: 2.943

1 in total