OBJECTIVE: The aim was to develop a drug-drug interaction database (SFINX) to be integrated into decision support systems or to be used in website solutions for clinical evaluation of interactions. METHODS: Key elements such as substance properties and names, drug formulations, text structures and references were defined before development of the database. Standard operating procedures for literature searches, text writing rules and a classification system for clinical relevance and documentation level were determined. ATC codes, CAS numbers and country-specific codes for substances were identified and quality assured to ensure safe integration of SFINX into other data systems. Much effort was put into giving short and practical advice regarding clinically relevant drug-drug interactions. RESULTS: SFINX includes over 8,000 interaction pairs and is integrated into Swedish and Finnish computerised decision support systems. Over 31,000 physicians and pharmacists are receiving interaction alerts through SFINX. User feedback is collected for continuous improvement of the content. CONCLUSION: SFINX is a potentially valuable tool delivering instant information on drug interactions during prescribing and dispensing.
OBJECTIVE: The aim was to develop a drug-drug interaction database (SFINX) to be integrated into decision support systems or to be used in website solutions for clinical evaluation of interactions. METHODS: Key elements such as substance properties and names, drug formulations, text structures and references were defined before development of the database. Standard operating procedures for literature searches, text writing rules and a classification system for clinical relevance and documentation level were determined. ATC codes, CAS numbers and country-specific codes for substances were identified and quality assured to ensure safe integration of SFINX into other data systems. Much effort was put into giving short and practical advice regarding clinically relevant drug-drug interactions. RESULTS: SFINX includes over 8,000 interaction pairs and is integrated into Swedish and Finnish computerised decision support systems. Over 31,000 physicians and pharmacists are receiving interaction alerts through SFINX. User feedback is collected for continuous improvement of the content. CONCLUSION: SFINX is a potentially valuable tool delivering instant information on drug interactions during prescribing and dispensing.
Authors: Amit X Garg; Neill K J Adhikari; Heather McDonald; M Patricia Rosas-Arellano; P J Devereaux; Joseph Beyene; Justina Sam; R Brian Haynes Journal: JAMA Date: 2005-03-09 Impact factor: 56.272
Authors: Amy J Grizzle; Maysaa H Mahmood; Yu Ko; John E Murphy; Edward P Armstrong; Grant H Skrepnek; William N Jones; Gregory P Schepers; W Paul Nichol; Antoun Houranieh; Donna C Dare; Christopher T Hoey; Daniel C Malone Journal: Am J Manag Care Date: 2007-10 Impact factor: 2.229
Authors: David N Juurlink; Muhammad Mamdani; Alexander Kopp; Andreas Laupacis; Donald A Redelmeier Journal: JAMA Date: 2003-04-02 Impact factor: 56.272
Authors: S H Sindrup; K Brøsen; P Bjerring; L Arendt-Nielsen; U Larsen; H R Angelo; L F Gram Journal: Clin Pharmacol Ther Date: 1990-12 Impact factor: 6.875
Authors: S H Sindrup; L Arendt-Nielsen; K Brøsen; P Bjerring; H R Angelo; B Eriksen; L F Gram Journal: Eur J Clin Pharmacol Date: 1992 Impact factor: 2.953
Authors: Annemieke Floor-Schreudering; Arjen F J Geerts; Jeffrey K Aronson; Marcel L Bouvy; Robin E Ferner; Peter A G M De Smet Journal: Eur J Clin Pharmacol Date: 2013-12-05 Impact factor: 2.953
Authors: Hans-Georg Eichler; Eric Abadie; Alasdair Breckenridge; Bruno Flamion; Lars L Gustafsson; Hubert Leufkens; Malcolm Rowland; Christian K Schneider; Brigitte Bloechl-Daum Journal: Nat Rev Drug Discov Date: 2011-07-01 Impact factor: 84.694
Authors: Linda Björkhem-Bergman; Eva Andersén-Karlsson; Richard Laing; Eduardo Diogene; Oyvind Melien; Malena Jirlow; Rickard E Malmström; Sabine Vogler; Brian Godman; Lars L Gustafsson Journal: Eur J Clin Pharmacol Date: 2013-05-03 Impact factor: 2.953
Authors: Gunnar Alván; Marine L Andersson; Annika B Asplund; Ylva Böttiger; Carl-Eric Elwin; Lars L Gustafsson; Birgitta Öhman; Elisabeth Törnqvist Journal: Eur J Clin Pharmacol Date: 2013-05-03 Impact factor: 2.953