Tinuade Ogunlesi1, Mojisola Ogundeyi, Adebiyi Olowu. 1. Department of Pediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria. tinude_ogunlesi@yahoo.co.uk
Abstract
OBJECTIVE: To determine the prevalence, aetiology and clinical pattern of childhood epilepsies in a Nigerian tertiary hospital. METHODS: A review of hospital records of children managed for epilepsies at the Pediatric Neurology Clinic. Data studied included the age at presentation, sex, socio-economic class, probable aetiology, clinical type of seizure, Electroencephalopgraphic (EEG) pattern and presence of other neurologic disorders co-existing with seizures. RESULTS: Out of 183 children, 138 had epilepsies giving a prevalence of 75.4%. Sixty nine (54.7%) were aged 6 months to 3 years at the first visit and 115 (69.9%) belonged to lower socio-economic classes IV and V. Birth asphyxia 47 (37.3%) and brain infections in 28 (21.9%) were the leading aetiologies. Generalized tonic-clonic seizures, complex partial seizures and rolandic seizures occurred in 55 (76.9%), 8 (6.3%) and 2 (4.8%) children respectively. Inter-ictal EEG abnormalities were recorded among 72/77 children. Seizures co-existed with other neurologic deficits in 86 (68.3%) of all epileptic cases. 95 (75.4%) children had defaulted from the clinic as at the time of the study. 21 (19.6%) had poor response to drug treatment. Presence of other neurological disorders (p = 0.029) and multiple aetiologies (p = 0.0000) were associated with poor response to drug treatment. CONCLUSION: Most cases of childhood epilepsy in Sagamu, Nigeria are due to preventable perinatal and neonatal conditions. Therefore, improved obstetric and neonatal care may reduce the prevalence of this condition.
OBJECTIVE: To determine the prevalence, aetiology and clinical pattern of childhood epilepsies in a Nigerian tertiary hospital. METHODS: A review of hospital records of children managed for epilepsies at the Pediatric Neurology Clinic. Data studied included the age at presentation, sex, socio-economic class, probable aetiology, clinical type of seizure, Electroencephalopgraphic (EEG) pattern and presence of other neurologic disorders co-existing with seizures. RESULTS: Out of 183 children, 138 had epilepsies giving a prevalence of 75.4%. Sixty nine (54.7%) were aged 6 months to 3 years at the first visit and 115 (69.9%) belonged to lower socio-economic classes IV and V. Birth asphyxia 47 (37.3%) and brain infections in 28 (21.9%) were the leading aetiologies. Generalized tonic-clonic seizures, complex partial seizures and rolandic seizures occurred in 55 (76.9%), 8 (6.3%) and 2 (4.8%) children respectively. Inter-ictal EEG abnormalities were recorded among 72/77 children. Seizures co-existed with other neurologic deficits in 86 (68.3%) of all epileptic cases. 95 (75.4%) children had defaulted from the clinic as at the time of the study. 21 (19.6%) had poor response to drug treatment. Presence of other neurological disorders (p = 0.029) and multiple aetiologies (p = 0.0000) were associated with poor response to drug treatment. CONCLUSION: Most cases of childhood epilepsy in Sagamu, Nigeria are due to preventable perinatal and neonatal conditions. Therefore, improved obstetric and neonatal care may reduce the prevalence of this condition.
Authors: H T Rwiza; G P Kilonzo; J Haule; W B Matuja; I Mteza; P Mbena; P M Kilima; G Mwaluko; R Mwang'ombola; F Mwaijande Journal: Epilepsia Date: 1992 Nov-Dec Impact factor: 5.864
Authors: Kathryn J Burton; Jane Rogathe; Roger Whittaker; Kshitij Mankad; Ewan Hunter; Matthew J Burton; Jim Todd; Brian G R Neville; Richard Walker; Charles R J C Newton Journal: Epilepsia Date: 2012-02-06 Impact factor: 5.864
Authors: Kenneth Ayuurebobi Ae-Ngibise; Bright Akpalu; Anthony Ngugi; Albert Akpalu; Francis Agbokey; Patrick Adjei; Damien Punguyire; Christian Bottomley; Charles Newton; Seth Owusu-Agyei Journal: Pan Afr Med J Date: 2015-05-13