Literature DB >> 19204377

Unexpected expression pattern of tetracycline-regulated transgenes in mice.

M Bao-Cutrona1, P Moral.   

Abstract

In generating a conditional transgenic murine model based on a tetracycline-regulated system, we obtained unexpected patterns of expression due to the transcriptional inactivity of the tet-responder promoter. Here we show strong cell-type-restricted expression that was variegated to an extent determined by the number of responder transgene copies integrated into the host genome.

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Year:  2009        PMID： 19204377      PMCID： PMC2666531          DOI： 10.1534/genetics.108.097600

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  29 in total

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