Literature DB >> 19203575

An amino acid shuffle activates mTORC1.

Adiel Cohen1, Michael N Hall.   

Abstract

The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.

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Year:  2009        PMID： 19203575     DOI： 10.1016/j.cell.2009.01.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  22 in total

1.  The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.

Authors:  Jacky Chung; Daniel E Bauer; Alireza Ghamari; Christopher P Nizzi; Kathryn M Deck; Paul D Kingsley; Yvette Y Yien; Nicholas C Huston; Caiyong Chen; Iman J Schultz; Arthur J Dalton; Johannes G Wittig; James Palis; Stuart H Orkin; Harvey F Lodish; Richard S Eisenstein; Alan B Cantor; Barry H Paw
Journal:  Sci Signal       Date:  2015-04-14       Impact factor: 8.192

2.  Persistent hyperinsulinemic hypoglycemia of infancy: constitutive activation of the mTOR pathway with associated exocrine-islet transdifferentiation and therapeutic implications.

Authors:  Sanda Alexandrescu; Nina Tatevian; Oluyinka Olutoye; Robert E Brown
Journal:  Int J Clin Exp Pathol       Date:  2010-08-08

3.  Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation.

Authors:  S Heublein; S Kazi; M H Ogmundsdóttir; E V Attwood; S Kala; C A R Boyd; C Wilson; D C I Goberdhan
Journal:  Oncogene       Date:  2010-05-24       Impact factor: 9.867

4.  Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells.

Authors:  Erika M Palmieri; Alessio Menga; Aurore Lebrun; Douglas C Hooper; D Allan Butterfield; Massimiliano Mazzone; Alessandra Castegna
Journal:  Antioxid Redox Signal       Date:  2016-11-02       Impact factor: 8.401

Review 5.  mTOR, metabolism, and the regulation of T-cell differentiation and function.

Authors:  Adam T Waickman; Jonathan D Powell
Journal:  Immunol Rev       Date:  2012-09       Impact factor: 12.988

6.  The role of LAT1 in (18)F-DOPA uptake in malignant gliomas.

Authors:  Ryan S Youland; Gaspar J Kitange; Timothy E Peterson; Deanna H Pafundi; Judi A Ramiscal; Jenny L Pokorny; Caterina Giannini; Nadia N Laack; Ian F Parney; Val J Lowe; Debra H Brinkmann; Jann N Sarkaria
Journal:  J Neurooncol       Date:  2012-10-20       Impact factor: 4.130

7.  Drosophila expresses a CD98 transporter with an evolutionarily conserved structure and amino acid-transport properties.

Authors:  Bruno Reynolds; Pietro Roversi; Robert Laynes; Shubana Kazi; C A Richard Boyd; Deborah C I Goberdhan
Journal:  Biochem J       Date:  2009-05-27       Impact factor: 3.857

8.  E2F1 regulates cellular growth by mTORC1 signaling.

Authors:  Sebastian Real; Nathalie Meo-Evoli; Lilia Espada; Albert Tauler
Journal:  PLoS One       Date:  2011-01-24       Impact factor: 3.240

9.  vProtein: identifying optimal amino acid complements from plant-based foods.

Authors:  Peter J Woolf; Leeann L Fu; Avik Basu
Journal:  PLoS One       Date:  2011-04-22       Impact factor: 3.240

Review 10.  Target of rapamycin (TOR) in nutrient signaling and growth control.

Authors:  Robbie Loewith; Michael N Hall
Journal:  Genetics       Date:  2011-12       Impact factor: 4.562
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