OBJECTIVE: To document haemopoietic stem cell transplantation (HSCT) activity and trends among paediatric patients in Australia and New Zealand. DESIGN, SETTING AND PARTICIPANTS: A retrospective analysis of data reported to the Australasian Bone Marrow Transplant Recipient Registry by the seven paediatric HSCT institutions in Australia and New Zealand over the 9-year period 1998-2006, with particular focus on the most recent years (2002-2006). MAIN OUTCOME MEASURES: Types of HSCT performed; transplant-related mortality (TRM); stem cell sources; indications for HSCT; causes of death after HSCT. RESULTS: Over the period 1998-2006, 522 autologous HSCT procedures (41%) and 737 allogeneic procedures (59%) were performed. About 60% of allogeneic transplants involved alternative donors (donors other than a human leukocyte antigen-matched sibling). The use of umbilical cord blood as a source of haemopoietic stem cells has doubled since 1998, with 34% of allogeneic transplants in 2006 using cord blood. Over the period 2002-2006, the median age of patients receiving transplants was 7 years (range, 0-19 years). The most common indications for allogeneic HSCT were acute lymphoblastic leukaemia (33%) and acute myeloid leukaemia (24%). The most common indications for autologous HSCT were neuroblastoma (23%), medulloblastoma (21%) and Ewing sarcoma (10%). TRM at 1 year after transplant was 22% for alternative donor transplants, 7% for matched-sibling transplants and 5% for autologous transplants. Relapse or persistence of a child's underlying condition accounted for 54% of all deaths within 1 year after transplant. CONCLUSIONS: HSCT is an important procedure for children with a range of life-threatening illnesses. Local trends in the indications for HSCT, donor selection and TRM reflect contemporary international practice.
OBJECTIVE: To document haemopoietic stem cell transplantation (HSCT) activity and trends among paediatric patients in Australia and New Zealand. DESIGN, SETTING AND PARTICIPANTS: A retrospective analysis of data reported to the Australasian Bone Marrow Transplant Recipient Registry by the seven paediatric HSCT institutions in Australia and New Zealand over the 9-year period 1998-2006, with particular focus on the most recent years (2002-2006). MAIN OUTCOME MEASURES: Types of HSCT performed; transplant-related mortality (TRM); stem cell sources; indications for HSCT; causes of death after HSCT. RESULTS: Over the period 1998-2006, 522 autologous HSCT procedures (41%) and 737 allogeneic procedures (59%) were performed. About 60% of allogeneic transplants involved alternative donors (donors other than a human leukocyte antigen-matched sibling). The use of umbilical cord blood as a source of haemopoietic stem cells has doubled since 1998, with 34% of allogeneic transplants in 2006 using cord blood. Over the period 2002-2006, the median age of patients receiving transplants was 7 years (range, 0-19 years). The most common indications for allogeneic HSCT were acute lymphoblastic leukaemia (33%) and acute myeloid leukaemia (24%). The most common indications for autologous HSCT were neuroblastoma (23%), medulloblastoma (21%) and Ewing sarcoma (10%). TRM at 1 year after transplant was 22% for alternative donor transplants, 7% for matched-sibling transplants and 5% for autologous transplants. Relapse or persistence of a child's underlying condition accounted for 54% of all deaths within 1 year after transplant. CONCLUSIONS: HSCT is an important procedure for children with a range of life-threatening illnesses. Local trends in the indications for HSCT, donor selection and TRM reflect contemporary international practice.
Authors: A A Hussein; A A Hamidieh; A Elhaddad; M Ramzi; T B Othman; F Hussain; D Dennison; P Ahmed; M Abboud; A Al-Ahmari; A Wahadneh; J Fathy; M-A Bekadja; S Al-Kindi; S Benchekroun; A Ibrahim; M Behfar; M Samra; S Ladeb; S Adil; H El-Solh; M Ayas; M Aljurf; A Ghavamzadeh; A Al-Seraihy Journal: Bone Marrow Transplant Date: 2016-09-12 Impact factor: 5.483
Authors: Alois Gratwohl; Helen Baldomero; Michael Gratwohl; Mahmoud Aljurf; Luis Fernando Bouzas; Mary Horowitz; Yoshihisa Kodera; Jeff Lipton; Minako Iida; Marcelo C Pasquini; Jakob Passweg; Jeff Szer; Alejandro Madrigal; Karl Frauendorfer; Dietger Niederwieser Journal: Haematologica Date: 2013-03-18 Impact factor: 9.941
Authors: Marion K Mateos; Tracey A O'Brien; Cecilia Oswald; Melissa Gabriel; David S Ziegler; Richard J Cohn; Susan J Russell; Draga Barbaric; Glenn M Marshall; Toby N Trahair Journal: Pediatr Blood Cancer Date: 2013-06-03 Impact factor: 3.167